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FLASH GENE
Symbol TIMM44 contributors: npt/ - updated : 28-12-2005
HGNC name translocase of inner mitochondrial membrane 44 homolog (yeast)
HGNC id 17316
Location 19p13.2      Physical location : 7.991.603 - 8.008.708
Synonym name mitochondrial inner membrane translocase
Synonym symbol(s) TIM44, MIMT44, DKFZp686H05241
DNA
TYPE functioning gene
STRUCTURE 16.94 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1897 51.22 452 - Bauer (1999)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas   highly
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a coiled-coil motif
  • a matrix-targeting segment with six positively charged residues
  • HOMOLOGY
    interspecies homolog to murine Timm44
    homolog to C.elegans T09B4.9
    Homologene
    FAMILY
  • TIMM44 family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • translocating nuclear-encoded proteins into the mitochondrion
  • recruiting mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with the matrix heat shock protein HSP70
  • forming part of the receptor complex consisting of at least three different proteins TIM17, TIM23, TIM44
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • binding to TIM17, TIM23, TIM44 and HSP70
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS