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FLASH GENE
Symbol TIMM44 contributors: npt/ - updated : 28-12-2005
HGNC name translocase of inner mitochondrial membrane 44 homolog (yeast)
HGNC id 17316
Location 19p13.2      Physical location : 7.991.603 - 8.008.708
Synonym name mitochondrial inner membrane translocase
Synonym symbol(s) TIM44, MIMT44, DKFZp686H05241
DNA
TYPE functioning gene
STRUCTURE 16.94 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
P114-RHO-GEF 19p13.3 angiopoietin-like 4 PEX11G 19p13.2 peroxisomal biogenesis factor 11 gamma FLJ35784 19p13.3 FLJ35784 protein ZNF358 19p13.3 zinc finger protein 358 MCOLN1 19p13.3-13.2 mucolipin 1 NTE 19p13.3-p13.2 mucolipin 1 KIAA1543 19p13.3-p13.2 mucolipin 1 XAB2 19p13.3 XPA binding protein 2 MGC41903 STXBP2 19p13.3-p13.2 syntaxin binding protein 2 RETN 19p13.3 resistin LOC199675 19p13.3 hypothetical protein LOC199675 TRAPPC5 19p13.3 trafficking protein particle complex 5 FCER2 19p13.3 Fc fragment of IgE, low affinity II, receptor for (CD23A) UNQ431 19p13.3 DTTR431 CD209 19p13 CD209 antigen CD209L 19p13.3 CD209 antigen-like LOC390879 19 similar to DTTR431 LOC115704 19p13.3 similar to ecotropic viral integration site 5; Neuroblastoma stage 4S gene LOC388499 19 similar to lysophospholipase II; acyl-protein thioesterase FLJ23420 19p13.3 hypothetical protein FLJ23420 MAP2K7 19p13.2 mitogen-activated protein kinase kinase 7 LOC388500 19 LOC388500 SNAPC2 19q13.3-p13.2 small nuclear RNA activating complex, polypeptide 2, 45kDa TIMM44 19p13.3-p13.2 translocase of inner mitochondrial membrane 44 homolog (yeast) ELAVL1 19p13.2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) CCL25 19p13.2 chemokine (C-C motif) ligand 25 FBN3 19p13 fibrillin 3 LASS4 19p13.3 LAG1 longevity assurance homolog 4 (S. cerevisiae) 8D6A 19p13.3-p13.2 LAG1 longevity assurance homolog 4 (S. cerevisiae) NDUFA7 19p13.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa RPS28 19p13.2 ribosomal protein S28 FLJ46061 19p13.3 FLJ46061 protein ANGPTL4 19p13.3 angiopoietin-like 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1897 51.22 452 - Bauer (1999)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas   highly
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a coiled-coil motif
  • a matrix-targeting segment with six positively charged residues
    • HOMOLOGY
    interspecies homolog to murine Timm44
    homolog to C.elegans T09B4.9
    Homologene
    FAMILY
  • TIMM44 family
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • translocating nuclear-encoded proteins into the mitochondrion
  • recruiting mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with the matrix heat shock protein HSP70
  • forming part of the receptor complex consisting of at least three different proteins TIM17, TIM23, TIM44
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • binding to TIM17, TIM23, TIM44 and HSP70
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS