Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TIMM21 contributors: mct - updated : 22-05-2019
HGNC name translocase of inner mitochondrial membrane 21
HGNC id 25010
Location 18q22.3      Physical location : -
Synonym name
  • HSPC154 protein
  • chromosome 18 open reading frame 55
  • TIM21-like protein, mitochondrial
  • Synonym symbol(s) HSPC154, C18orf55, TIM21
    DNA
    TYPE functioning gene
    STRUCTURE 10.46 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1562 - 248 - 2012 23260140
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma   
    Epithelialbarrier liningendometrium  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • is dispensable for protein import but required for integration of early-assembling, presequence-containing subunits into respiratory-chain intermediates
  • in mitochondria, TIMM21 shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes
  • does not associate with mature cytochrome c oxidase complexes but rather represents a constituent of assembly intermediates
  • TIMM21 is the first assembly factor that is involved in the transfer of newly imported proteins from the presequence translocase to assembling respiratory-chain complexes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the inner-membrane presequence translocase, and is also present in the major assembly intermediates containing newly mitochondria-synthesized and imported respiratory-chain subunits, the MITRAC complexes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TIM21, a specific subunit of the sorting-active presequence translocase, recruits proton-pumping respiratory-chain complexes and stimulates preprotein insertion
  • TIMM21 could shuttle between TIMM23 and MITRAC complexes to fulfill a more direct function in the assembly process of nuclear-encoded subunits into assembly intermediates
  • C-terminal sequence of TIMM23 is dispensable for growth and functions as an inhibitor for binding of TIMM21
  • while ROMO1 is dispensable for general protein import along the presequence pathway, it participates in the dynamics of TIMM21 during respiratory chain biogenesis and is specifically required for import of YME1L
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS