basic FUNCTION
| involved in circadian oscillation autoregulation and in regulation of meiotic chromosome cohesion |
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inhibiting CLOCK-BMAL1-induced transactivation |
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may play an important role in epithelial cell morphogenesis and formation of branching tubules |
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required for CK2 effects on PER, and is an important mediator of CK2 effects on circadian rhythms |
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TIMELESS-TIPIN complex stabilizes replication forks both by preventing the accumulation of ssDNA upstream of ATR-CHEK1 function and by facilitating phosphorylation of CHEK1 by ATR  |
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required for ATM-dependent activation of CHEK2 and G2/M checkpoint arrest  |
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TIMELESS has a function in sister chromatid cohesion (SCC) that is independent of the TIMELESS-TIPIN complex, even though the abundance of TIMELESS is reduced when TIPIN is targeted for depletion  |
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coordinates mitotic kinase activation with termination of DNA replication  |
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functions together with TERF1 to prevent fork collapse at telomere repeat DNA and ensure stable maintenance of telomere length and integrity  |
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implicated in circadian rhythms as well as cell cycle control and embryonic development  |
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TIMELESS is responsible for the interaction between the TIMELESS-TIPIN and Mcm complexes  |
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TIMELESS-TIPIN complex plays important roles in S phase progression, stabilization of stalled replication forks, and checkpoint activation  |
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TIMELESS-mediated fork protection may represent a way to cooperate with BRCA-dependent fork stabilization  |