basic FUNCTION
| acting as an isomerase |
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functioning by blocking glycolysis and directing the pathway into the pentose phosphate shunt |
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functions as a regulator of glycolysis, and therefore has a relationship with glucose as well as energy |
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TP53-inducible gene that inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate, an activator of glycolysis and inhibitor of gluconeogenesis ( |
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protecting cells from DNA damaging reactive oxygen species |
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providing some protection from DNA damage-induced apoptosis |
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involved in down-regulation of glycolysis, reduction of intracellular levels of reactive oxygen species, and protection from apoptosis |
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can modulate ROS in response to nutrient starvation or metabolic stress, and functions to inhibit autophagy |
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inhibits proliferation of cancer cells and increases drug-mediated tumour regression by promoting p53-mediated cell-cycle arrest |
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acts as a fructose-2,6-bisphosphatase, potentially promoting the pentose phosphate pathway to produce NADPH for antioxidant function and ribose-5-phosphate for nucleotide synthesis |
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TIGAR inhibits both apoptosis and autophagy, resulting in a dual impact on tumor cell survival in response to tumor chemotherapy |
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under low ischemic burden, TIGAR activation induces the pentose phosphate pathway and autophagy as a protective mechanism |
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TIGAR expression changes during development and its expression level may be likely correlated with the vulnerability of neurons to ischemic injury |
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TIGAR-regulated pentose phosphate pathway (PPP) plays a critical role in the neuronal survival during cerebral ischemia/reperfusion |
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inhibits ischemia/reperfusion-induced inflammatory response of astrocytes |
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role for TIGAR in modulating redox homeostasis during oocyte maturation, |
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is a TP53 target protein that plays critical roles in glycolysis and redox balance |
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glycolytic inhibitor, plays vital roles in regulating cellular metabolism and oxidative stress |
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overexpression of mitochondrial-TIGAR enhanced ATP generation, maintained mitochondrial membrane potential and reduced mitochondrial oxidative stress under hypoxia condition |
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promotes metabolic reprogramming and regulates neural stem cells (NSCs) differentiation through an epigenetic mechanism |
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has anti-epileptic, anti-oxidant and anti-apoptotic effects |
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activates the pentose phosphate pathway (PPP), which feeds reduced nicotinamide adenine dinucleotide phosphate (NADPH) to the antioxidant glutathione pathway |
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TIGAR may have an anti-apoptosis effect via up-regulation of autophagy in diabetic neuropathy |