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FLASH GENE
Symbol TICRR contributors: mct/pgu - updated : 25-04-2013
HGNC name chromosome 15 open reading frame 42
HGNC id 28704
Location 15q26.1      Physical location : -
Genatlas name TopBP1-interacting, checkpoint, and replication regulator
Synonym name
  • leucine-rich repeat kinase 1
  • treslin
  • TopBP1-interacting, replication-stimulating protein
  • Synonym symbol(s) MGC45866, FLJ41618, C15orf42, treslin
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 52.44 kb     22 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 6688 211 1910 - 2004 15146197
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to Sld3
    Homologene
    FAMILY
  • TICRR family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulates a pivotal step in the initiation of DNA replication in vertebrates
  • required to prevent mitotic entry after treatment with ionizing radiation
  • essential for normal cell cycle progression
  • acts in association with TOPBP1 and plays an essential role in preinitiation complex formation
  • necessary for deoxyribonucleic acid (DNA) replication
  • like TOPBP1, is a dual replication/checkpoint protein that directly participates in ATR-mediated checkpoint signaling
  • initiation factor Treslin coordinating the assembly and activation of the eukaryotic replication fork helicase by recruiting CDC45 to MCM2-7
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TOPBP1 (associates with TOPBP1 in a Cdk2-dependent manner)
  • GINS1, GINS2, GINS3, GINS4 and TICRR compete with one another for MCM2-7 and CDC45 binding
  • associated with TOPBP1 in a CDK-regulated manner in cells and TICRR was phosphorylated within a conserved CDK consensus target sequence
  • TICRR stimulates ATR phosphorylation of CHEK1 in a TOPBP1-dependent manner
  • coordinates the assembly and activation of the eukaryotic replication fork helicase by recruiting CDC45 to MCM2-7, stimulating DDK phosphorylation of MCM2, and binding directly to single-stranded DNA as the origin is melted
  • cell & other
    REGULATION
    Phosphorylated by CDK-mediated phosphorylation of TICRR during S phase is necessary for both its effective association with TOPBP1 and its ability to promote DNA replication in human cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS