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FLASH GENE
Symbol TICAM2 contributors: mct - updated : 18-10-2017
HGNC name toll-like receptor adaptor molecule 2
HGNC id 21354
Location 5q22.3      Physical location : 114.914.339 - 114.938.109
Synonym name
  • TIR-containing adapter molecule-2
  • TRIF-related adaptor molecule
  • Toll/interleukin-1 receptor
  • Toll/IL-1R domain-containing adaptor inducing IFN-beta
  • TIR domain containing adaptor-inducing interferon-beta
  • Synonym symbol(s) TRAM, TICAM-2, TIRP, TIRAP3, TRIF
    DNA
    TYPE functioning gene
    STRUCTURE 23.84 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3074 - 235 - 2003 14519765
    - - - - - - 2009 19412184
  • 'TICAM2 adaptor with GOLD domain', which has a Golgi dynamics domain coupled to TICAM2
  • inhibited activation of IRF3 by lipopolysaccharide
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
     stomach    
    Lymphoid/Immunelymph node    
    Reproductivefemale systembreastmammary gland  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a central TIR domain that is most similar to that of TRIF
    HOMOLOGY
    Homologene
    FAMILY Toll/interleukin-1 receptor (TIR) family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,granule
    text
  • localized in the plasma membrane and the Golgi apparatus, where it colocalizes with TLR4
  • localized to late endosomes positive for the GTPase RAB7a (
  • basic FUNCTION
  • involved in IL-1-triggered NF-kappaB activation and functions upstream of IRAK, IRAK2, TRAF6, and IKBKB
  • functions exclusively in the TLR4 pathway (
  • playing a crucial role in lipopolysaccharide-TLR4-mediated activation of IFN-beta
  • couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
  • signaling pathway promotes TNF-alpha mRNA translation through activation of the protein kinase MAP2K2 (
  • mediating TLR3 signaling and MYD88-independent signaling of TLR4, and playing an inhibitory role in TLR5-elicited responses by inducing proteolytic degradation of TLR5
  • can participate in proteolytic modification of certain members of TLRs to modulate the functionality of TLRs at post-translational level
  • adaptor molecule, recruited to TLR3 and -4 upon agonist stimulation and triggering activation of IFN regulatory factor 3 (IRF3) and expression of type 1 IFNs, which are critical for cellular antiviral responses
  • acts as a sorting adaptor not only for TLR4, but also for TLR2, to facilitate signaling to IRF7 at the endosome, which explains how TLR2 is capable of causing type I IFN induction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TBC1D23 likely acts downstream of the TLR-signaling adaptors MYD88 and TICAM2 and upstream of the transcription factor XBP1
  • TICAM2 serves as the sorting adaptor for MYD88 in IL18 signaling, which then facilitates the signal transduction
  • critical role for ARF6 in regulating TICAM2/TICAM1-dependent TLR4 signaling
  • role for TICAM2 in TLR4-mediated signaling in regulating inflammatory responses via its interaction with TRAF6, distinct from its role as a bridging adaptor between TLR4 and TICAM1
  • plays a, hitherto unappreciated, role in TLR7 signaling through a novel signaling axis containing, but not limited to, MYD88, TICAM2 and IRF3 towards the activation of anti-viral immunity
  • is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement
  • TLR4 recruits TICAM2 as a sorting adaptor to facilitate the interaction between TLR4 and TICAM1 and then initiate TICAM1-dependent IRF3 activation
  • TICAM2 bridges TLR4 and TICAM1 for LPS signaling in the endosome
  • ANXA2 directly exerted negative regulation of inflammatory responses through TLR4-initiated TICAM2-TICAM1 pathway occurring on endosomes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility for tuberculosis (TB)
    Variant & Polymorphism other association between TICAM2 polymorphisms and TB
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS