protein
| toll-like receptor adaptor molecule 2, TICAM2 |
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TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates NF-kappa B and IFN-regulatory factor-3 |
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IRF-7 and IRF-3 |
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NAK-associated protein 1, NAP1 |
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TNF receptor-associated factor, TRAF1 |
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TICAM1-signaling pathway promotes TNF-alpha mRNA translation through activation of the protein kinase MAPKAPK2 |
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toll-like receptor 5, TLR5 |
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UBQLN1 is a novel inhibitor of the TLR3-TICAM1 antiviral pathway by reducing the abundance of TICAM1 |
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DEFB103B affects the activity of pro-inflammatory pathways associated with MYD88 and TICAM1 |
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regulatory impact of IRAK1/4 and PELI3 on the TICAM1-dependent TLR4-signaling cascade, which might be of general importance for disease conditions associated with macrophage pathologies such as atherosclerosis |
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ADAM15 is a novel TCAM1-interacting partner |
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is an adapter protein required for TLR3-mediated signaling |
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WWP2 is a TICAM1-associated protein by biochemical purification (WWP2 mediated K48-linked ubiquitination and degradation of TICAM1 upon TLR3 activation) |
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physical association of TLR9, ICAM1 and TRAF6 leads to activation of noncanonical NFKB1 signalling |
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critical role for ARF6 in regulating TICAM2/TICAM1-dependent TLR4 signaling |
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WDFY1 recruits the signaling adaptor TICAM1 to TLR3 and TLR4, thereby potentiating signaling from these pattern recognition receptors (PRRs) |
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TLR4 recruits TICAM2 as a sorting adaptor to facilitate the interaction between TLR4 and TICAM1 and then initiate TICAM1-dependent IRF3 activation |
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TICAM2 bridges TLR4 and TICAM1 for LPS signaling in the endosome |
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important distinction between the TICAM1-mediated signaling pathways of TLR4 and TLR3 |
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ANXA2 directly exerted negative regulation of inflammatory responses through TLR4-initiated TICAM2-TICAM1 pathway occurring on endosomes |
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is required for optimal activation of innate immune responses in mesothelial cells against microbial infections |
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regulated foam cell formation via regulation of the expression levels of CCL2, F3, OLR1 |
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TRIM32 negatively regulates TLR3/4-mediated immune responses by targeting TICAM1 to TAX1BP1-mediated selective autophagic degradation |
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USP19 interacts with TICAM1 and catalyzes the removal of TICAM1 K27-linked polyubiquitin moieties, thereby impairing the recruitment of TICAM1 to TLR3/4 |
| germline mutation Lps2 abolishing cytokine responses to double-stranded mRNA and severely impairing responses to the endotoxin lipopolysaccharide (LPS) | |
mice genetically deficient in both MyD88 and TRIF have a complete lack of known TLR signaling |
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Trif-deficient mice by target disruption are defective in both TLR3- and TLR4-mediated expression of IFN-beta and activation of IRF-3 |
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mice deficient in both MyD88 and TRIF show complete loss of nuclear factor kappa B activation in response to TLR4 stimulation |
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TRIF-KO intestinal epithelial cells exhibited substantially reduced inflammatory cytokine and TRIF-KO mice are resistant to in vivo intestinal inflammatory responses |