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FLASH GENE
Symbol TIAM2 contributors: SGE/npt - updated : 29-01-2008
HGNC name T-cell lymphoma invasion and metastasis 2
HGNC id 11806
Location 6q25.2      Physical location : 155.411.422 - 155.578.856
Synonym name SIF and TIAM1-like exchange factor
Synonym symbol(s) STEF, FLJ41865, TIAM-2, KIAA2016
DNA
TYPE functioning gene
STRUCTURE 167.44 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text lacking the EX and PDZ motifs
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 5916 - 1701 - Suzuki (2004)
  • isoform a
  • 13 splicing 2668 - 626 - Suzuki (2004)
  • isoform b
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum highly
     brainbasal nucleiputamen  
     brainforebraincerebral lobefrontal lobe 
     brainforebraincerebral lobeoccipital lobe 
     brainforebraincerebral lobetemporal lobe 
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • from the N terminus, a pleckstrin homology domain
  • a coiled coil region
  • an EX domain
  • the DHR/PDZ (PSD95/disc large/ZO-1) domain
  • a DBL homology domain (DH) modulating the activity of Rac1
  • RHO-like protein
  • PH domain
  • a TSS domain, necessary for the membrane localization of STEF and Rac1 activation, and binding specifically RAP1A active form
  • conjugated LipoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Tiam2 (85.1pc)
    Homologene
    FAMILY
  • TIAM family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text localizes to the plasma membrane in neurites
    basic FUNCTION
  • involved in neural cell development
  • modulating the balance of Rho GTPase activities in the growth cone and, consequently, to control growth cone behavior
  • guanine nucleotide exchange factor for RAC1, involved in regulating APP processing
  • regulating cell migration by microtubule-mediated focal adhesion disassembly throug hthe activation of RAC1 (Rooney 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAP1A, MAP1B, PARP1, YWHAE
  • cell & other
    REGULATION
    activated by a physical interaction between its TSS domain and Rap1
    GTP which mediates Rac1 activation and this active form of Rac regulates the alpha cleavage of APP
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS