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FLASH GENE
Symbol TIAL1 contributors: mct/pgu - updated : 03-10-2011
HGNC name TIA1 cytotoxic granule-associated RNA binding protein-like 1
HGNC id 11804
Location 10q26.11      Physical location : 121.332.977 - 121.356.541
Synonym name
  • T-cluster binding protein
  • TIA-1-related nucleolysin
  • TIA-1 related protein
  • Synonym symbol(s) TCBP, TIAR, MGC33401
    DNA
    TYPE functioning gene
    STRUCTURE 23.57 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387713 10 similar to ventral anterior homeobox 1 TRIK 10q26.12 TWIK-related spinal cord K+ channe SLC18A2 10q25 solute carrier family 18 (vesicular monoamine), member 2 LOC118987 10q26.12 hypothetical protein LOC118987 LOC387714 10 LOC387714 EMX2 10q26.1 empty spiracles homolog 2 (Drosophila) Rab11-FIP2 10q26.12 KIAA0941 protein C10orf5 10q26.12 chromosome 10 open reading frame 5 FLJ13188 10q26.12 hypothetical protein FLJ13188 GPR10 10q25.3-q26 G protein-coupled receptor 10 LOC390007 10 similar to Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog) (hTom22) (1C9-2) C10orf46 10q26.12-q26.13 chromosome 10 open reading frame 46 LOC88066 10q26.13 similar to 60S ribosomal protein L17 (L23) NANOS1 10q26.13 nanos homolog 1 (Drosophila) EIF3S10 10q26 eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa SFXN4 10q26.12 sideroflexin 4 PRDX3 10q25-q26 peroxiredoxin 3 GPRK5 10q24-qter G protein-coupled receptor kinase 5 RGS10 10q25 regulator of G-protein signalling 10 TIAL1 10q26.11 TIA1 cytotoxic granule-associated RNA binding protein-like 1 LOC119563 10q26.13 similar to 40S ribosomal protein S8 BAG3 10q25.2-q26.2 BCL2-associated athanogene 3 LOC93202 10q26.13 thioredoxin 1 pseudogene 2 INPP5F 10q26.13 inositol polyphosphate-5-phosphatase F FLJ13081 10q26.13 hypothetical protein FLJ13081 SEC23IP 10q25-q26 SEC23 interacting protein LOC338570 10q26.13 similar to alpha NAC/1.9.2. protein LOC196051 10q26.13 hypothetical protein LOC196051 WDR11 10q26 WD repeat domain 11 FGFR2 10q26 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) ATE1 10q26.13 arginyltransferase 1 FLJ20003 10q26.13 hypothetical protein FLJ20003
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 splicing 3894 41.6 375 - 2007 17486099
  • possessing a lysosome-targeting motif in its C-terminal auxiliary domain
  • lacking exons 1 and 4
  • 12 splicing 3945 - 392 - 2007 17486099
  • utilizing a later translation initiation site
  • possessing a T-cluster DNA-binding region in its C-terminal auxiliary domain
  • lacking exon 2
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver    
    Endocrinepancreas    
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three N-terminal RNA recognition motifs (RRMs)
  • a C-terminal glutamine-rich (Q-rich) domain
  • HOMOLOGY
    interspecies homolog to murine Tial1
    homolog to Drosophila CG4787
    homolog to C.elegans C18A3.5a
    intraspecies homolog to TIA-1
    Homologene
    FAMILY
  • a family of RNA-binding proteins
  • CATEGORY RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,granule
    text cytotoxic granule-associated protein/cytoplasmic granules of cytolytic T-lymphocytes
    basic FUNCTION
  • possessing nucleolytic activity against cytotoxic lymphocyte target cells
  • MYC translational suppressor, involved in the induction of apoptosis
  • repressing PF4 exression
  • inducing DNA fragmentation in permeabilized cells
  • inducing apoptosis in cytolytic lymphocyte (CTL) targets
  • controling proliferation with HNRPD by a MYC-dependent pathway
  • with NANOS3 would play critical functions in posttranscriptional regulations in primordial germ cells soon after their specification
  • TIA1, and TIAL1 are mRNA-binding proteins that can aggregate within granules under specific stress conditions
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription activating factor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding to fragment DNA in permeabilized target cells
  • binding to the PF4 promoter T-cluster and the proximal T-rich region
  • RNA binding specifically to poly(A) homopolymers
    small molecule
    protein
  • TIA1 and TIAL1 proteins are intron-associated positive regulators of SMN2 exon 7 splicing
  • cell & other
    REGULATION
    Other rapid and severe hypoxia caused co-aggregation of TIAL1/TIA1 and these proteins suppressed HIF1A expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the thyroid tissues in patients with Graves disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS