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FLASH GENE
Symbol THY1 contributors: mct/pgu - updated : 20-10-2012
HGNC name Thy-1 cell surface antigen
HGNC id 11801
Location 11q23.3      Physical location : 119.288.655 - 119.294.246
Genatlas name Thymus cell antigen 1
Synonym name
  • Thy-1 co-transcribed
  • CD90 antigen
  • Thy-1 antigen
  • Thy-1 membrane glycoprotein
    • Synonym symbol(s) CD90, FLJ33325, LOC94105, THY1CT, CDw90
    DNA
    TYPE functioning gene
    STRUCTURE 5.59 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see BALMCR ,AT ,CD3@ ,HMBS
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2413 17 161 - 2000 1094446
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphatic vessel   highly Homo sapiens
    Nervousbrain   highly
     nerve   highly
    Respiratorylung     Homo sapiens
    Urinarykidney   highly
    Visualeyeretina    Rattus norvegicus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificfibroblast Homo sapiens
    cell lineage
    cell lines tumor endothelial cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an immunoglobulin-like V-type domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Thy1
    homolog to C.elegans C48E7.7
    Homologene
    FAMILY
  • immunoglobulin superfamily
    • CATEGORY antigen , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • playing a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain
  • putative tumor suppressor gene for ovarian cancer
  • adhesion molecule on activated endothelial cells (ECs) mediating the adhesion of neutrophils via the interaction with ITGB2
  • pivotal roles on activated dermal EC or fibroblasts and its counter receptor CD18 on neutrophils for the regulation of MMP9 and CXCL8 release from neutrophils
  • positive-selection marker for the isolation of cancer stem cells in some case of T-acute lymphoblastic leukemia
  • in myofibroblasts is not just a marker, but is a functional protein that transmits signals into the cell, up-regulating its FASLG expression
  • lymphatic vessel expressed gene, suggesting its potential role in the cell adhesion processes required for tumor progression and inflammation
  • involved in the control of inflammatory cell recruitment and, thus, also in conditioning the inflammatory microenvironment
  • functions as a tumor suppressor in ovarian cancer and in nasopharyngeal carcinoma
  • may play a critical role in the generation of tumor vasculatures in glioma via differentiation into endothelial cells
  • promoted lipofibroblast differentiation via the expression of PPARG, stimulated lipid accumulation via fatty-acid esterification, and enhanced the fatty-acid uptake mediated by fatty-acid transporter proteins
  • important in the regulation of lipofibroblast differentiation in the developing lung
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • neutrophil interaction with THY1 stimulated secretion of CXCL8 and thus could support the attraction of additional neutrophils to inflammatory sites
  • CD97, present on peripheral myeloid cells, is a novel interacting partner for THY1 (is an interacting partner for CD97 on activated endothelial cells)
  • colocalizes and coimmunoprecipitates potentially with a membrane-spanning protein HCN4 in retina
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in ovarian cancer
    tumoral     --low  
    in nasopharyngeal carcinoma, which is significantly associated with lymph node metastases
    constitutional       gain of function
    increasing neutrophil adherence in psoriasis
    constitutional     --low  
    in lung fibroblasts induces a fibrogenic phenotype (idiopathic pulmonary fibrosis)
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumour suppressor gene in nasopharyngeal carcinoma
    Marker
  • could provide a clinical prognostic marker forhepatocellular carcinoma
  • potential prognostic marker for high-grade gliomas but also a marker for cancer stem cells within gliomas
    • Therapy target
    ANIMAL & CELL MODELS