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FLASH GENE
Symbol THRSP contributors: mct/npt - updated : 27-05-2015
HGNC name thyroid hormone responsive (SPOT14 homolog, rat)
HGNC id 11800
Location 11q14.1      Physical location : 77.774.906 - 77.779.396
Synonym name
  • spot 14 protein
  • thyroid hormone-inducible hepatic protein
  • thyroid hormone-responsive protein
  • Synonym symbol(s) SPOT14, S14, MGC21659, LPGP1, Lpgp, THRP
    DNA
    TYPE functioning gene
    STRUCTURE 4.49 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure
  • four LXR response-element-like elements and one sterol regulatory element (SRE)-binding site within a -2,468 &
  • 8764;+1-base-pair region of the THRSP promoter
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC387790 11 LOC387790 C11orf30 11q13.5 chromosome 11 open reading frame 30 GARP 11q13.5-q14 glycoprotein A repetitions predominant LOC390226 11 similar to Olfactory guanylyl cyclase GC-D precursor (Guanylate cyclase, olfactory) E2IG4 11q13.3 hypothetical protein, estradiol-induced PHCA 11q13.4 phytoceramidase, alkaline IMAGE:4907098 11q13.4 beta-1,3-N-acetylglucosaminyltransferase protein CAPN5 11q14 calpain 5 OMP 11q13 olfactory marker protein MYO7A 11q13.5 myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)) LOC220032 11q13.4 GDPD domain containing protein LOC387791 11 similar to Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) PAK1 11q13.5-q14.1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) LOC387792 11 LOC387792 AQP11 11q13.4 aquaporin 11 CLNS1A 11q13.5-q14.1 chloride channel, nucleotide-sensitive, 1A HBXAP 11q13.4-q14.1 hepatitis B virus x associated protein PTD015 11q13.4 PTD015 protein MGC16733 11q13.4 hypothetical gene MGC16733 similar to CG12113 KCTD14 11q13.4 potassium channel tetramerisation domain containing 14 THRSP 11q13.5 thyroid hormone responsive (SPOT14 homolog, rat) NDUFC2 11q12.1-q13.14 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa ALG8 11pter-p15.5 asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase) LOC387793 11 hypothetical gene supported by BC062331 LOC387794 11 similar to ubiquitin specific protease 38; HP43.8KD protein USP35 11q13.4 ubiquitin specific protease 35 GAB2 11q13.4-q13.5 GRB2-associated binding protein 2 FLJ23441 11q13.4 hypothetical protein FLJ23441 ODZ4 11q13.4 odd Oz/ten-m homolog 4 LOC387795 11 LOC387795
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1182 16.5 146 - 2007 17418816
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Nervousbrainlimbic systemhippocampusdentate gyrus  Mus musculus
    Reproductivefemale systembreastmammary gland   Homo sapiens
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • potential transactivation activity of THRSP is regulated by its C-terminal region
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Spot 14
    intraspecies homolog to thyroid hormone responsive spot 14
    paralog to MID1IP1
    Homologene
    FAMILY
  • Spot 14 superfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in lipogenesis in liver, mammary and adipose tissues
  • it plays a role in the regulation of lipogenic enzymes during tumorigenesis
  • playing a role in thyroid hormone receptor -dependent transcriptional activation of the expression of specific genes
  • role in the TP53-dependent transcriptional activation of specific genes via diverse pathways in cells
  • is required for normal lipogenesis in the lactating mammary gland, but not the liver
  • implicated in supporting regulated lipogenesis
  • both MID1IP1 and THRSP are directly involved in supporting hepatic lipogenesis and that the two proteins play overlapping roles in this process
  • carbohydrate-inducible and thyroid-hormone-inducible nuclear protein specific to liver, adipose and lactating mammary tissues
  • functions to activate genes encoding fatty-acid synthesis enzymes
  • playing a role in thyroid hormone stimulation of lipogenesis
  • modulates malonyl-CoA levels and de novo lipogenesis
  • regulates de novo fatty acid synthesis in the liver, adipose, and lactating mammary gland
  • potential role in regulating mammary tumor growth and fatty acid synthesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein , other
    signaling hormonal
    thyroid
    a component
  • THRSP can form heterodimers with MID1IP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically and functionally interacts with thyroid receptor in the regulation of malic enzyme gene expression
  • involved both in the regulation of malic enzyme promoter activity, and in the regulation of TP53-dependent transactivation
  • seems to act as a molecular brake on FASN-dependent lipogenesis, potentially also integrating other signals, such as thyroid hormone-regulated pathways
  • stimulated fatty acid synthase (FASN) activity in vitro, and increased the synthesis of fatty acids in mammary epithelial cells in vivo
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in breast tumor with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS