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FLASH GENE
Symbol THRAP3 contributors: mct/ - updated : 19-03-2016
HGNC name thyroid hormone receptor associated protein 3
HGNC id 22964
Location 1p34.3      Physical location : 36.690.016 - 36.770.955
Synonym name thyroid hormone receptor-associated protein complex 150 kDa component
Synonym symbol(s) TRAP150, KIAA0164, FLJ22082, MGC133082, MGC133083
DNA
TYPE functioning gene
STRUCTURE 80.94 kb     12 Exon(s)
regulatory sequence Promoter
text structure
  • contains E-box sequences in its promoter
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4447 - 955 - 2010 20123736
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrainhindbraincerebellumcerebellar cortex 
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an arginine/serine-rich domain and has sequence similarity with the cell death-promoting transcriptional repressor BCLAF1
  • one LISH domain
  • a RS-rich domain very likely contributing to its splicing activation activity
  • C-terminal region with a motif homologous to CASC3 and BCLAF1
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    text
  • co-localizes with splicing factors in nuclear speckles, and is required for pre-mRNA splicing and activates splicing
    • basic FUNCTION
  • may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus
  • plays a role in transcriptional coactivation
  • with GSK3, play a role in the complex network that regulates PTPRC alternative splicing
  • can trigger mRNA degradation in the nucleus
  • multi-functional protein involved in nuclear mRNA metabolism, in pre-mRNA splicing and, unexpectedly, in nuclear mRNA degradation
  • acts as a splicing activator and may participate in a step that is critical for pre-mRNA splicing in cells but not in the extract
  • role for RNA processing factor THRAP3 in the DNA damage response
  • could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARG-mediated gene activation cooperatively with HELZ2
  • BCLAF1 has functions distinct from THRAP3 in regulating the subcellular distribution of mRNAs in human cells
  • promotes CLOCK-ARNTL binding to target genes and links CLOCK-ARNTL to the transcriptional machinery at target-gene promoters
  • is itself clock-regulated, and its coactivator function creates a positive feedback loop nested within the core circadian negative feedback loop
  • RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the transcription regulatory complex TRAP/Mediator, and component of the spliceosome
  • is a constituent of endogenous ARNTL complexes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with DKC1, nop5/nap65 and fibrillarin
  • association with the mRNA export factor NXF1
  • associates with a small subset of Mediator complexes in its function as a transcriptional coactivator, but it is not considered to be a structural component of Mediator
  • both THRAP3 and BCLAF1 are associated with the spliceosome, indicating their potential role in pre-mRNA splicing
  • HELZ2 interacts with the serine/arginine-rich domain and BCL2 associated transcription factor1-homologous region in THRAP3, whereas THRAP3 directly binds 2 helicase motifs in HELZ2
  • promotes the binding of CLOCK-ARNTL to DNA and links it to the basic transcriptional machinery
  • potently and selectively promotes the binding of CLOCK-ARNTL to circadian target genes
  • THRAP3 interacts with dimeric SFPQ to block access of RNA to RRM2, thereby regulating the activity of SFPQ toward a broad set of splicing events in T cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS