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FLASH GENE

Symbol

THRA

contributors: mct - updated : 03-06-2020

HGNC name	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
HGNC id	11796

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.1      Physical location : 38.218.445 - 38.250.118
Synonym name	thyroid hormone receptor, alpha (oncogene ERBA1)
	avian erythroblastic leukemia viral (v-erb-a) oncogene homolog
	ERBA-related 7
	triiodothyronine receptor
Synonym symbol(s)	ERBA1, NR1A1, THRA1, THRA2, THRA3, AR7, EAR-7.1, EAR-7.2, EAR7, ERB-T-1, ERBA-ALPHA, ERBA, MGC000261, ERB-T-1, MGC43240, RHTA

DNA

TYPE	functioning gene
SPECIAL FEATURE	opposite orientation
text	encoding NR1D1 (alpha transcript) on the opposite orientation strand (see symbol)
STRUCTURE	31.67 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_199334 9 - 2405 NP_955366 46.8 410 - 2009 19628582 hormone binding receptor NM_003250 10 splicing 2474 NP_003241 54.8 490 - 2009 19628582 not binding hormone but inhibiting THR transactivation NM_001190918 10 splicing 2449 isoform 3 50.7 451 - 2009 19628582 NM_001190919 10 - 2547 54.8 490 - 2009 19628582

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive male system prostate     highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	in embryonic postmitotic neurons

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal modulator domain,
	a central bipartite (class II) zinc finger DNA binding domain
	a C terminal ligand domain

HOMOLOGY

Homologene

FAMILY	steroid/thyroid hormone receptor superfamily
	nuclear hormone receptor family

CATEGORY

transcription factor , signaling hormone , receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
text	shuttles rapidly between the nucleus and cytoplasm (

basic FUNCTION	nuclear hormone receptor for triiodothyronine mediating the biological activities of thyroid hormone
	exhibits a dual role as an activator or repressor of its target genes in response to thyroid hormone (T(3)(
	apparently plays an essential role in restoring the expression of the TH-regulated genes potentially involved in striatal synaptic plasticity (
	has the capacity to play an important role in virtually all developing and adult neurons
	is required for normal neural progenitor cell proliferation in human cerebral cortical development

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

thyroid

a component

INTERACTION

DNA

RNA

small molecule

protein	directly interacts with calreticulin (THRA can follows a cooperative export pathway in which both calreticulin and CRM1 play a role in facilitating efficient translocation of THRA from the nucleus to cytoplasm) (
	thyroid hormone (TH), a regulator of hepatic gluconeogenesis acts through its nuclear receptor (THRA, THRB) to induce the expression of PCK1 and G6PC

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   dysregulated in breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual   inhibition of THRA, THRB locally in the retina is a therapeutic strategy for retinal degeneration

ANIMAL & CELL MODELS

thyroid receptor knock-out mouse models displaying severe neurological dysfunction