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FLASH GENE
Symbol THOP1 contributors: - updated : 13-05-2006
HGNC name thimet oligopeptidase 1
HGNC id 11793
Location 19q13.3      Physical location : 2.785.505 - 2.813.590
Synonym name endopeptidase 24.15
Synonym symbol(s) EP24.15, MP78
EC.number 3.4.24.15
DNA
TYPE functioning gene
STRUCTURE 28.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LSM7 19p13.3 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) SPPL2B 19p13.3 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) LOC360200  polyserase 1 TIMM13 19p13.3 translocase of inner mitochondrial membrane 13 homolog (yeast) LMNB2 19p13.3 lamin B2 GADD45B 19p13.3 growth arrest and DNA-damage-inducible, beta FLJ00058 19p13.3 hypothetical protein FLJ00058 GNG7 19p13.3 guanine nucleotide binding protein (G protein), gamma 7 LOC390875 19 similar to fos39347_1 DIRAS1 19p13.3 DIRAS family, GTP-binding RAS-like 1 LOC388490 19 LOC388490 SLC39A3 19p13.3 solute carrier family 39 (zinc transporter), member 3 SGTA 19p13 small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha THOP1 19p13.3 thimet oligopeptidase 1 FLJ34817 19p13.3 hypothetical protein FLJ34817 MGC26707 19p13.3 hypothetical protein MGC26707 FLJ11637 19p13.3 hypothetical protein FLJ11637 LOC126295 19p13.3 hypothetical protein LOC126295 ZNF77 19p zinc finger protein 77 (pT1) FLJ14009 19p13.3 transducin-like enhancer protein 6 TLE2 19p13.3 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) AES 19p13.3 amino-terminal enhancer of split GNA11 19p13.3 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) LOC390876 19 similar to ribosomal protein L35 GNA15 19p13.3 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) LOC388491 19 similar to KIAA1683 protein EDG6 19p13.3 endothelial differentiation, G-protein-coupled receptor 6 LOC56926 19p13.3 hypothetical protein from EUROIMAGE 2021883
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunetonsils   highly
Nervousbrain    
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to rattus metalloendopeptidase 24.15
Homologene
FAMILY peptidase m3 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • involved in antigen presentation via MHC class 1
  • beta secretase, catalyzing the degradation of somatostatin peptide from APP
  • involved in the metabolism of neuropeptides under 20 amino acid residues long
  • able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments
  • play a major role in degrading proteasome products
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 1 zinc ion per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS