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FLASH GENE
Symbol THOP1 contributors: - updated : 13-05-2006
HGNC name thimet oligopeptidase 1
HGNC id 11793
Location 19q13.3      Physical location : 2.785.505 - 2.813.590
Synonym name endopeptidase 24.15
Synonym symbol(s) EP24.15, MP78
EC.number 3.4.24.15
DNA
TYPE functioning gene
STRUCTURE 28.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunetonsils   highly
Nervousbrain    
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to rattus metalloendopeptidase 24.15
Homologene
FAMILY peptidase m3 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • involved in antigen presentation via MHC class 1
  • beta secretase, catalyzing the degradation of somatostatin peptide from APP
  • involved in the metabolism of neuropeptides under 20 amino acid residues long
  • able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments
  • play a major role in degrading proteasome products
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 1 zinc ion per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS