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Symbol THOC7 contributors: mct/npt - updated : 21-03-2009
HGNC name THO complex 7 homolog (Drosophila)
HGNC id 29874
Location 3p14.1      Physical location : 63.819.546 - 63.849.597
Synonym name
  • Ngg1 interacting factor 3 like 1 binding protein 1
  • THO complex subunit 7 homolog
  • Synonym symbol(s) FLJ23445, NIF3L1BP1
    DNA
    TYPE functioning gene
    STRUCTURE 30.05 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1028 23 204 - El Bounkari (2009)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Respiratoryrespiratory tractlarynx   
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative leucine zipper domain
  • C-terminal region of 100 AAs sufficient for the interaction with NIF3L1 (Taskou 2003)
  • HOMOLOGY
    Homologene
    FAMILY
  • THOC7 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • In the absence of exogenous THOC5, THOC7 resides mainly in the cytoplasm, while in the presence of THOC5, THOC7 is transported into the nucleus with THOC5
  • basic FUNCTION
  • involved in mRNA processing (El Bounkari 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of the THO complex that associate with the mRNA export apparatus (El Bounkari 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding partner of NIF3L1
  • THOC7 (50137, amino acid numbers) binds to the N-terminal portion (1199) of THOC5 directly (THOC7/THOC5 interaction is required for nuclear localization of THOC7)(El Bounkari 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS