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FLASH GENE
Symbol THOC1 contributors: mct/npt - updated : 06-01-2015
HGNC name THO complex 1
HGNC id 19070
Location 18p11.32      Physical location : 214.521 - 268.059
Synonym name nuclear matrix protein p84
Synonym symbol(s) P84, HPR1, P84N5, Tho1, THO
DNA
TYPE functioning gene
STRUCTURE 53.54 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2133 75.5 657 - 2005 15998806
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • death domain
  • HOMOLOGY
    Homologene
    FAMILY
  • TREX (transcription/export) complex
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text colocalizes with splicing factors in nuclear speckle domains (Masuda 2005)
    basic FUNCTION
  • regulating transcriptional elongation and may participate in a protein complex functionally analogous to yeast TREX, physically linking elongating RNA polymerase II with RNA processing factors
  • THOC1-mediated RNP assembly contributes to the coordinated expression of genes necessary for normal differentiation and development
  • prevents R-loop formation and has a role in genome dynamics and function consistent with an evolutionary conservation of the functional connection between these mRNP biogenesis factors and genome integrity that had not been anticipated
  • ALYREF, THOC1 and DDX39B form a highly integrated unit to associate with the spliced mRNA and function in mRNA export
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the TREX (transcription/export) complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RB1
  • interaction with NXF1 through UBA domain, required to bind polyubiquitin, possibly by inducing an H4-dependent conformational change (Hobeika 2007)
  • NEDD4 functions in conjunction with other post-translational mechanisms to regulate THOC1 protein and THO activity
  • overexpression of NFE2L2 suppressed THOC1 promoter activity in an ARE-dependent manner
  • nuclear matrix protein that binds to the retinoblastoma tumor suppressor retinoblastoma protein (RB1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    common in non-small cell lung cancer and may have prognostic significance in subgroups of patients (Yang 2008)
    tumoral     --over  
    in breast cancer and expression levels correlate with tumor size and metastatic potential(depletion of Thoc1 protein (pThoc1) in cancer cell lines compromises cell proliferation) (Li 2007)
    tumoral     --over  
    in ovarian and lung tumors
    constitutional     --over  
    can inhibit cell proliferation, induce G2/M cell cycle arrest and promote apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a functionally relevant molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may provide a novel molecular target for cancer therapy
    cancerlung 
    may be used as a novel therapeutic target for human lung cancer treatment
    ANIMAL & CELL MODELS
  • murine Thoc1 deletion disrupts homeostasis within the small intestine but does not have detectable effects in other epithelial tissues such as the related mucosa of the large intestine
  • Thoc1 deletion prevents prostate cancer progression in mice, but has little effect on normal tissue