Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

THEM4

contributors: mct - updated : 21-03-2011

HGNC name	thioesterase superfamily member 4
HGNC id	17947

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q21      Physical location : 151.846.059 - 151.882.113
Synonym name	C-terminal modulator protein
Synonym symbol(s)	MGC29636, CTMP, RP11-139D23.3-001

DNA

TYPE	functioning gene
STRUCTURE	36.05 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_053055 6 splicing 2224 27 240 - 2001 11598301 variant 2 - splicing 1849 12 107 - 2001 11598301 including an alternate exon causing a frameshift compared to variant 1

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   stomach       specific Reproductive female system uterus cervix   moderately   female system placenta     moderately   female system breast mammary gland   highly   male system prostate     moderately Skin/Tegument skin       highly Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
text	localized to mitochondria
	exhibits a dual sub-mitochondrial localization as a membrane-bound pool and a free pool of mature THEM4 in the inter-membrane space

basic FUNCTION	negatively regulating AKT activity by inhibiting phosphorylation
	enhances various cellular activities that are principally mediated by the PI3-kinase/Akt pathway
	delays AKT phosphorylation following cell death induction, suggesting that THEM4 regulates apoptosis via inhibition of AKT
	in addition to its role in AKT inhibition, may therefore play a key role in mitochondria-mediated apoptosis by localizing to mitochondria

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	AKT inhibitor that binds to its hydrophobic motif
	association with heat shock protein 70 (Hsp70) inhibits the formation of complexes containing apoptotic protease activating factor 1 and Hsp70
	consistently associated with leucine zipper/EF-hand-containing transmembrane-1 (LETM1)
	ATF3 downregulated the mRNA and protein levels of THEM4

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS