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FLASH GENE
Symbol THBS3 contributors: mct - updated : 21-08-2013
HGNC name thrombospondin 3
HGNC id 11787
Location 1q22      Physical location : 155.165.380 - 155.177.690
Synonym symbol(s) TSP3
DNA
TYPE functioning gene
STRUCTURE 12.40 kb     23 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
text structure binding sites for heparin
MAPPING cloned Y linked   status provisional
Physical map
PMVK 1p13-q23 phosphomevalonate kinase PBXIP1 1q22 pre-B-cell leukemia transcription factor interacting protein 1 PYGO2 1q22 pygopus 2 SHC1 1q21 SHC (Src homology 2 domain containing) transforming protein 1 CKS1B 1q21.2 CDC28 protein kinase regulatory subunit 1B PP591 1q22 FAD-synthetase LENEP 1q22 lens epithelial protein ZFP67 1q21.2 zinc finger protein 67 homolog (mouse) FLJ32934 1q22 hypothetical protein FLJ32934 FLJ32785 1q22 hypothetical protein FLJ32785 ADAM15 1q21.3 a disintegrin and metalloproteinase domain 15 (metargidin) EFNA4 1q21-q22 ephrin-A4 EFNA3 1q21-q22 ephrin-A3 EFNA1 1q21-q22 ephrin-A1 LOC55974 1q22 stromal cell protein DPM3 1q21.2 dolichyl-phosphate mannosyltransferase polypeptide 3 KCP2 TRIM46 1q21-22 tripartite motif-containing 46 MUC1 1q21 mucin 1, transmembrane THBS3 1q21-q23 thrombospondin 3 MTX1 1q21 metaxin 1 LOC388704 1 similar to GBA protein MTX1P 1q21 metaxin 1 pseudogene GBA 1q21 glucosidase, beta; acid (includes glucosylceramidase) C1orf2 1q21 chromosome 1 open reading frame 2 SCAMP3 1q21 secretory carrier membrane protein 3 CLK2 1q21 CDC-like kinase 2 HCN3 1q22 hyperpolarization activated cyclic nucleotide-gated potassium channel 3 PKLR 1q21 pyruvate kinase, liver and RBC FDPS 1q21.2 farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) FLJ35976 1q22 hypothetical protein FLJ35976 RUSC1 1q21-q22 RUN and SH3 domain containing 1 ASH1L 1q21 ash1 (absent, small, or homeotic)-like (Drosophila)
regionally located . a new exon, exon A', which replaces exon A. Exon A' is located in the TSP3/metaxin intergenic region, 1 kb 5' of exon A (PMID: 10527891)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2891 - 836 - 1999 10527891
22 - 3224 - 947 - 1999 10527891
23 - 3251 - 951 - 1999 10527891
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheartvalve    Homo sapiens
Digestivestomach   highly
Reproductivemale systemtestis  highly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Epithelialbarrier/lining   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • four type II (EGF-like)
  • seven type III (Ca++ binding) repeats
  • a TSP C-terminal (TSPC) domain
  • a TSP N-terminal (TSPN) domain
  • conjugated GlycoP
    mono polymer pentamer
    HOMOLOGY
    interspecies homolog to murine Thbs3
    Homologene
    FAMILY thrombospondin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,nuclear envelope
    basic FUNCTION
  • playing a unique role in cell matrix interactions
  • adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions
  • highly conserved matricellular protein regulating inflammation, angiogenesis and extracellular matrix remodeling
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component oligomer disulfide-linked
    INTERACTION
    DNA
    RNA
    small molecule
    protein bind to fibrinogen, fibronectin, laminin and type V collagen
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS