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FLASH GENE
Symbol THAP11 contributors: mct/pgu - updated : 09-12-2014
HGNC name THAP domain containing 11
HGNC id 23194
Location 16q22.1      Physical location : 67.876.212 - 67.878.097
Synonym name RONIN
Synonym symbol(s) HRIHFB2206, CTG-B45d, CTG-B43a, RONIN
DNA
TYPE functioning gene
STRUCTURE 1.89 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC146206 16q22.1 hypothetical protein LOC146206 24432 16q22.1 hypothetical protein 24432 PARD6A 16q22.1 par-6 partitioning defective 6 homolog alpha (C.elegans) DKFZP434A1319 16q22.1 hypothetical protein DKFZp434A1319 LOC388284 16 hypothetical gene supported by BC032064; BC041612 MGC11335 16q22.1 hypothetical protein MGC11335 TSNAXIP1 16q22.2 translin-associated factor X interacting protein 1 FLJ13111 16q22.1 hypothetical protein FLJ13111 THAP11 16q22.1 THAP domain containing 11 NUTF2 16q22.2 nuclear transport factor 2 RCD-8 16q22.1 autoantigen UNQ2446 16q22.1 MRCC2446 PSKH1 16q22.1 protein serine kinase H1 CTRL 16q22.1 chymotrypsin-like PSMB10 16q22.1 proteasome (prosome, macropain) subunit, beta type, 10 LCAT 16q22.1 lecithin-cholesterol acyltransferase SLC12A4 16q22.1 solute carrier family 12 (potassium/chloride transporters), member 4 DPEP3 16q22.1 dipeptidase 3 DPEP2 16q22.1 dipeptidase 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1903 - 314 - 2008 18585351
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineparathyroid   highly
Nervousbrain    
Reproductivefemale systemuterus   
 female systemovary  highly
Respiratorylung   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a THAP domain associated with sequence-specific DNA binding and epigenetic silencing of gene expression
  • two poly-Ala domains
  • a poly-Gln domain
  • HOMOLOGY
    interspecies ortholog to murine Thap11
    ortholog to rattus thap11_predicted
    Homologene
    FAMILY
  • THAP11 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • essential factor underlying embryogenesis and embryonic stem cell pluripotency
  • may be an endogenous physiologic regulator of cell proliferation
  • functions as a cell growth suppressor by negatively regulating the expression of MYC
  • with others THAP proteins could play a major role in targeting genes to promote transcription regulation through interactions with protein complexes associated to chromatin remodelling
  • essential role for the self-renewal of embryonic stem cells
  • novel role of THAP11 in CD44 alternative splicing and hepatoma invasion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex THAP11/HCFC1 controls a genetic program that contributes to the unimpeded growth of embryonic stem cells
  • THAP11/ZNF143/HCFC1 complex is a critical component of the transcriptional regulatory network governing cell proliferation
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binds directly to HCFC1, a key transcriptional regulator (association with HCFC1 suggests an epigenetic mechanism of gene repression in pluripotent cells)
  • interacts with host cell factor-1 HCFC1, a key transcriptional regulator associated to chromatin remodelling
  • is a novel physiological binding partner of PCBP1
  • HCFC1 serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for neuropsychiatric disease, due to triplet repeats
    Marker
    Therapy target
    ANIMAL & CELL MODELS