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FLASH GENE
Symbol THADA contributors: SGE/npt - updated : 13-07-2010
HGNC name thyroid adenoma associated
HGNC id 19217
Location 2p21      Physical location : 43.457.975 - 43.823.185
Synonym name
  • thyroid adenoma associated protein
  • death receptor-interacting protein
  • gene inducing thyroid adenomas protein
  • Synonym symbol(s) GITA, FLJ21877, FLJ44016, FLJ44876, KIAA1767, FLJ77530
    DNA
    TYPE functioning gene
    STRUCTURE 365.21 kb     38 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391369 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC284397 2p22.1 similar to FKSG60 LOC391370 2 similar to ribosomal protein S12 LOC388942 2 hypothetical gene supported by AK126414 LOC285047 2p22.1 hypothetical LOC285047 LOC91461 2p22.1 hypothetical protein BC007901 EML4 2p22-p21 echinoderm microtubule associated protein like 4 COX7A2L 2p22.1-p16 cytochrome c oxidase subunit VIIa polypeptide 2 like LOC253584 2p22.1 hypothetical LOC253584 KCNG3 2p22.1 potassium voltage-gated channel, subfamily G, member 3 MTA3 2p21 potassium voltage-gated channel, subfamily G, member 3 TG1019 2p22.1 G-protein coupled receptor TG1019 HAAO 2p21 3-hydroxyanthranilate 3,4-dioxygenase LOC388943 2 similar to cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 ZFP36L2 2p22.3 zinc finger protein 36, C3H type-like 2 MGC40574 2p22.1 hypothetical protein MGC40574 THADA 2p22.1 thyroid adenoma associated KIAA2028 2p22.1 similar to PH (pleckstrin homology) domain D2LIC 2p25.1-p24.1 dynein 2 light intermediate chain ABCG5 2p21 ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1) ABCG8 2p21 ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) LRPPRC 2p21 leucine-rich PPR-motif containing PPM1B 2p22,1 protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform LOC391371 2 similar to 60S RIBOSOMAL PROTEIN L12 SLC3A1 2p16.3 solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 FLJ23451 2p22.1 hypothetical protein FLJ23451 SIX3 2p21-p16 sine oculis homeobox homolog 3 (Drosophila) LOC388944 2 LOC388944 SIX2 2p16-p15 sine oculis homeobox homolog 2 (Drosophila) LOC151111 2p21 hypothetical LOC151111
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    38 - 6134 - 1953 - Rippe (2003)
    38 - 6346 - 1953 - Rippe (2003)
    24 exons
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     liver   highly
     stomach    
    Endocrinepancreas    
     thyroid    
    Lymphoid/Immunethymus    
    Reproductivefemale systemuterus   
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Thada (79.8pc)
    homolog to murine Thada (79.0pc)
    Homologene
    FAMILY
  • THADA family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • a death receptor-interacting protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    aberrantly rearranged in thyroid adenomas (Drieschner 2007)
    Susceptibility to Polycystic ovary syndrome (PCOS)
    Variant & Polymorphism SNP associated with Polycystic ovary syndrome (PCOS)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS