Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TGS1 contributors: mct/npt - updated : 14-01-2009
HGNC name trimethylguanosine synthase homolog (S. cerevisiae)
HGNC id 17843
Location 8q12.1      Physical location : 56.685.790 - 56.738.003
Synonym name
  • hepatocarcinoma-associated antigen 137
  • PRIP-interacting protein with methyltransferase domain
  • nuclear receptor coactivator 6 interacting protein
  • PRIP-interacting protein PIPMT SEREX-defined
  • SEREX-defined
  • CLL-associated antigen KW-2
  • Synonym symbol(s) PIMT, PIPMT, HCA137, FLJ22995, NCOA6IP, DKFZp762A163
    EC.number 2.1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 52.21 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D8S509 - D8S165 - TGS1 - D8S1828 - D8S285 - D8S125 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3708 96 853 - Hausmann (2008)
    a minimal catalytic domain from AA 631 to 853 that sufficed for guanine-N2 methyltransferase activity
    - - - - 110 cytoplasmic Hausmann (2008)
    - - - 70 - nuclear Hausmann (2008)
    a C-terminal proteolytic fragment
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Lymphoid/Immunespleen    
    Reproductivemale systemprostate   
     male systemtestis   
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a long N-terminal extension not found in yeast Tgs1, which might exert effects on the intracellular localization, protein-protein interactions, or protein-nucleic acid interactions (Hausmann 2008)
  • a minimal catalytic domain from AA 631 to 853 that sufficed for guanine-N2 methyltransferase activity
  • a methyltransferase motif I
  • a motif found in K-homology domains of many RNA-binding proteins
  • HOMOLOGY
    interspecies ortholog to yeasr tgs1
    Homologene
    FAMILY
  • methyltransferase superfamily
  • trimethylguanosine synthase family
  • CATEGORY enzyme , transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • sperm head cytoskeletal structure
  • it is concentrated in Cajal bodies (Hausmann 2008)
  • basic FUNCTION
  • trimethylguanosine synthase may be involved in spermatid differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCOA6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS