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FLASH GENE
Symbol TGIF2LY contributors: SGE/npt - updated : 25-06-2010
HGNC name TGFB-induced factor homeobox 2-like, Y-linked
HGNC id 18569
Location Yp11.2      Physical location : 3.447.125 - 3.448.080
Synonym name
  • TGFB-induced factor 2-like protein, Y-linked
  • homeobox protein TGIF2LY
  • TGFI-like on the Y
  • TGF-beta-induced transcription factor 2-like protein
  • Synonym symbol(s) TGIFLY
    DNA
    TYPE functioning gene
    STRUCTURE 0.95 kb     2 Exon(s)    single Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ11323 Xp22.33; hypothetical protein FLJ11323 PGPL Xp22.33; pseudoautosomal GTP-binding protein-like PR48 Xp22.33; protein phosphatase 2A 48 kDa regulatory subunit LOC392571 Y LOC392571 LOC392572 Y LOC392572 SHOX Xp22.3 short stature homeobox LOC389913 Y LOC389913 IL3RA Xp22.3 interleukin 3 receptor, alpha (low affinity) SLC25A6 Xp22.32 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 FLJ13330 Xp22.33; hypothetical protein FLJ13330 ASMTL Xp22.3 acetylserotonin O-methyltransferase-like P2RY8 Xp22.33; purinergic receptor P2Y, G-protein coupled, 8 DXYS155E Xp22.32 DNA segment on chromosome X and Y (unique) 155 expressed sequence ASMT Xp22.3 acetylserotonin O-methyltransferase LOC392573 Y similar to trophinin; melanoma antigen, family D, 3; trophinin-2; magphinin-alpha; magphinin-gamma; magphinin-beta 2; necdin and trophinin like; melanoma antigen, family D, 3-like ALTE Xp22.33, Ac-like transposable element LOC389914 Y hypothetical gene supported by AK125149; BC019893 CD99 Xp22.32 CD99 antigen SRY Yp11.3 sex determining region Y RPS4Y Yp11.3 ribosomal protein S4, Y-linked ZFY Yp11.3 zinc finger protein, Y-linked LOC392574 Y similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase-epsilon) (LPAAT-epsilon) (1-acylglycerol-3-phosphate O-acyltransferase 5) LOC360018 Yp11.2 HBxAg transactivated protein 2 pseudogene TGIF2LY Yp11.2 TGFB-induced factor 2-like, Y-linked USP12P3 Yp11.2 ubiquitin specific protease 12 pseudogene 3 LOC359798 Yp11.2 ubiquitin-conjugating enzyme E2 variant 1 pseudogene LOC359996 Yp11.2 PAI-1 mRNA-binding protein pseudogene PCDH11Y Yp11.2 protocadherin 11 Y-linked LOC359800 Yp11.2 voltage-dependent anion channel 1 pseudogene LOC359792 Yp11.2 eukaryotic translation initiation factor 4A, isoform 1 pseudogene LOC360019 Yp11.2 keratin 18 pseudogene LOC347593 5q11.2 60S ribosomal protein L26 pseudogene LOC359794 Yp11.2 lung cancer candidate FUS1 pseudogene LOC360014 Yp11.2 discs, large homolog 7 (Drosophila) pseudogene TSPYQ1 Yq11.2 discs, large homolog 7 (Drosophila) pseudogene LOC389915 Y similar to CYorf16 protein LOC347584 Yp11.2 testis specific protein, Y-linked pseudogene LOC392575 Y similar to testis specific protein, Y-linked LOC378952 Yp11.2 RNA binding motif protein, Y-linked, family 2, pseudogene TTTY7 Y testis-specific transcript, Y-linked 7 AMELY Yp11.2 amelogenin (Y chromosome) LOC359997 Yp11.2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 pseudogene TBL1Y Yp11.2 transducin (beta)-like 1Y-linked LOC360029 Yp11.2 hypothetical protein BC016683 pseudogene GPR143P Yp11.2 G protein-coupled receptor 143 pseudogene PRKY Yp11.2 protein kinase, Y-linked LOC378953 Yp11.2 RNA binding motif protein, Y-linked, family 2, pseudogene LOC377997 Yp11.2 testis specific protein, Y-linked pseudogene LOC360015 Yp11.2 raft-linking protein pseudogene TTTY12 Yp11.1-q11.1 testis-specific transcript, Y-linked 12 LOC392576 Y similar to Zinc finger protein ZFD25
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 880 - 185 - Blanco-Arias (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one homeobox DNA-binding domain
  • HOMOLOGY
    Homologene
    FAMILY
  • TALE/TGIF homeobox family of transcription factors
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be acting as a regulator of TGIF2LX
  • may have a transcriptional role in testis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding
  • RNA
    small molecule
    protein
  • interacting with CTBP, MADH2, MADH3, HDAC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • association of TGIF2LY/X expression with the progression of prostate cancer (Ousati-Ashtiani 2009)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS