Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TGIF2 contributors: mct - updated : 29-03-2019
HGNC name TGFB-induced factor 2 (TALE family homeobox)
HGNC id 15764
Location 20q11.23      Physical location : 35.202.009 - 35.222.350
DNA
TYPE functioning gene
STRUCTURE 20.48 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure
  • contains a retained intron, within the second coding exon
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3456 - 237 - 2017 27956704
    3 - 3328 - 237 - 2017 27956704
    3 - 3415 - 237 - 2017 27956704
    3 - 3358 - 237 - 2017 27956704
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine  highly
     intestinelarge intestinecolon highly
     liver   highly
     mouthtongue  highly
     pancreas exocrine   moderately
    Lymphoid/Immunelymph node   predominantly
    Reproductivefemale systemovary  highly
     male systemtestis  moderately
     male systemprostate  moderately
    Respiratorylung   moderately
     lung   highly
     respiratory tractlarynx  moderately
    Skin/Tegumentskin   highly
    Urinarykidney    
    Visualeye   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative nuclear localization signal (NLS) helix turn helix
  • DNA binding domain
  • three AA loop extension between helices superfamily (TALE)
  • one proline-rich domain
  • HOMOLOGY
    interspecies ortholog to murine Tgif2
    intraspecies homolog to TGIF
    Homologene
    FAMILY TALE family homeobox
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcriptional repressor when bound to DNA via aTGIF binding site and recruiting histone deacetylase
  • TGIF2 acts primarily by restricting BMP signaling in the endoderm to allow pancreatic formation
  • is the molecular link between dorsoventral patterning of the endoderm and pancreatic specification
  • TGIF1, TGIF2 are transcriptional co-repressors that limit the response to TGFbeta signaling and play a role in regulating retinoic-acid-mediated gene expression
  • TGIF1, TGIF2 function is required for gastrulation, and provide the first clear evidence that Tgifs limit the transcriptional response to NODAL signaling during early embryogenesis
  • TGIF1, TGIF2 are transcriptional repressors that inhibit the transcriptional response to TGFB1 signaling, and can repress gene expression by direct binding to DNA
  • TGIF1, TGIF2 regulate axial patterning and reduced TGIF function sensitizes embryos to the effects of retinoic acid
  • participates likely in photoreceptor cell differentiation in the early stages of retinal development and regulates proper subretinal localization of the cone photoreceptors
  • TGIF1, TGIF2 regulate ciliogenesis and EVI5L mediates likely at least part of this effect
  • TGIF1, TGIF2 play an important role in regulating basic energy metabolism in normal cells, and this function of Tgifs is amplified in some cancers
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • histone deacetylase
  • TGIF1 and TGIF2 regulate the TGFB1/NODAL signaling pathway and sonic hedgehog (SHH) signaling independently
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in ovarian cancers cell lines
    constitutional germinal mutation     loss of function
    in both TGIF1 and TGIF2 result in a failure of gastrulation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS