basic FUNCTION
| down regulator of RXRA activities |
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SMAD2 (MADH2) binding protein and transcriptional corepressor |
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has an important role myelopoiesis and may regulate the balance between proliferation and differentiation |
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playing a key role in regulating retinoic acid signaling, and is essential to properly pattern the forebrain |
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its function is required for gastrulation, and provide the first clear evidence that Tgifs limit the transcriptional response to Nodal signaling during early embryogenesis |
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TGIF1, TGIF2 function is required for gastrulation, and provide the first clear evidence that Tgifs limit the transcriptional response to NODAL signaling during early embryogenesis |
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represses gene expression by interaction with general corepressors, and can be recruited to target genes by transforming growth factor beta (TGFB) activated Smads, or by the retinoid X receptor (RXR) |
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can regulate nuclear receptor complexes, in addition to those containing retinoic acid receptors |
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plays a role in radiation-induced normal tissue injury |
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promotes the endothelial cell inflammatory response after exposure to radiation or TNF |
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new role for TGIF1 as a proinflammatory molecule |
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is a transcriptional repressor that can modulate retinoic acid and transforming growth factor beta signaling pathways |
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regulates quiescence and self-renewal of hematopoietic stem cells |
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is a new player in human cholesterol metabolism |
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promoted the growth and migration of nonsmall cell lung cancer (NSCLC) cells |
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TGIF1, TGIF2 are transcriptional repressors that inhibit the transcriptional response to TGFB1 signaling, and can repress gene expression by direct binding to DNA |
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TGIF1, TGIF2 regulate axial patterning and reduced TGIF function sensitizes embryos to the effects of retinoic acid |
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regulates endothelial cells (ECs) function and the expression of angiogenic molecules |
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TGIF1, TGIF2 regulate ciliogenesis and EVI5L mediates likely at least part of this effect |
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TGIF1, TGIF2 play an important role in regulating basic energy metabolism in normal cells, and this function of Tgifs is amplified in some cancers |
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is a novel regulator of bone remodeling and an essential component of the PTH anabolic action |