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FLASH GENE
Symbol TGFB1I1 contributors: mct/npt/pgu - updated : 31-08-2016
HGNC name transforming growth factor beta 1 induced transcript 1
HGNC id 11767
Location 16p11.2      Physical location : 31.483.475 - 31.489.281
Synonym name
  • androgen receptor coactivator ARA55
  • hydrogen peroxide-inducible clone-5
  • Synonym symbol(s) TSC5, HIC5, ARA55, HIC-5, TSC-5
    DNA
    TYPE functioning gene
    STRUCTURE 5.80 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU   long interspersed repetitive elements
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC283932 16p11.2 hypothetical protein LOC283932 MGC13024 16p11.2 hypothetical protein MGC13024 KIAA0339 16p11 hypothetical protein MGC13024 HSD3B7 16p11.2-12 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 STX1B2 16p12-p11 syntaxin 1B2 STX4A 16p13.13-p12.3 syntaxin 4A (placental) FLJ13479 16p11.2 hypothetical protein FLJ13479 KIAA0296 16p13.13-p13.2 hypothetical protein FLJ13479 IMAGE3455200 BCKDK 16p11.2 branched chain alpha-ketoacid dehydrogenase kinase MYST1 16p11.2 MYST histone acetyltransferase 1 PRSS8 16p11.2 protease, serine, 8 (prostasin) FLJ90661 16p11.2 hypothetical protein FLJ90661 LOC390691 16 similar to Filamin B (FLN-B) (Beta-filamin) (Actin-binding like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP-280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1) FUS 16p11.2 fusion, derived from t(12;16) malignant liposarcoma ASC 16p12-p11.2 fusion, derived from t(12;16) malignant liposarcoma PYC1 16p11.2 pyrin-domain containing protein 1 ITGAM 16p11.2 integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide) ITGAX 16p11.2 integrin, alpha X (antigen CD11C (p150), alpha polypeptide) COX6A2 16p12-p11 cytochrome c oxidase subunit VIa polypeptide 2 MGC46336 16p11.2 hypothetical protein MGC46336 FLJ13063 16p11.2 hypothetical protein FLJ13063 TGFB1I1 16p11 transforming growth factor beta 1 induced transcript 1 SLC5A2 16p11.2 solute carrier family 5 (sodium/glucose cotransporter), member 2 FLJ13868 16p11.2 hypothetical protein FLJ13868 ERAF 16p11.1 erythroid associated factor LOC388247 16 similar to cold shock domain protein A; Cold-shock domain protein A LOC342426 16p11.2 similar to zinc finger protein 267; zinc finger (C2H2) MGC3020 16p11.2 hypothetical protein MGC3020 LOC124411 16p11.2 hypothetical protein LOC124411 VN1R3 16p11.2 vomeronasal 1 receptor 3 LOC390692 16 similar to hypothetical protein FLJ10290 ZNF267 16p11.1 zinc finger protein 267 LOC388248 16 similar to KIAA1501 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1813 - 461 - 1999 10075738
    11 - 1812 55 444 - 1999 10075738
    - - 1782 - 444 - 1999 10075738
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveesophagus   highly
     intestinesmall intestine  highly
    Nervousbrain    
    Reproductivefemale systemuterus  highly
    Urinarykidney    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
     fibroblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text prostate
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four LD motifs at the N terminus
  • four LIM motifs binded to two zinc ions at the C terminus, LIM domain-containing C-terminal half binds to a conserved alternatively spliced exon in LEF/TCF transcription factors, and is sufficient to interact with AR ; LIM2 and LIM3 domains were necessary and sufficient for TGFB1I1 to form a complex with MMP14
  • HOMOLOGY
    interspecies homolog to murineTgfb1i1
    intraspecies homolog to PXN
    Homologene
    FAMILY
  • paxillin family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text ability to shuttle between the nuclear and cytoplasmic compartments was revealed on inhibition of nuclear export with leptomycin B
    basic FUNCTION
  • acting as a coactivator for the androgen receptor (AR)
  • has a role in the stromal-epithelial interaction involved in fetal prostate development
  • repressor of lymphoid enhancer factor/T-cell factor (LEF1)-driven transcription
  • stromal-specific AR coactivator that has an effect on an androgen-regulated growth factor that is essential for stromal/epithelial cell communication in the prostate
  • may play very important roles in the progression of prostate cancer by the modulation of AR transactivation
  • molecular regulator for androgen sensitivity in human hair follicles
  • functions as a cell-type-specific activator of TGF-beta signaling through its ability to physically interact with and neutralize SMAD7
  • its expression contributes to prostate tumorigenesis and castrate responsiveness
  • transforming growth factor-beta-inducible LIM protein whose deregulation is implicated in the progression of prostate cancer
  • roles for paxillin and TGFB1I1 in RAC1 and RHOA-dependent cell adhesion formation and maturation, processes essential for productive cell migration
  • is a versatile coregulator that acts by multiple gene-specific mechanisms that influence genomic occupancy of NR3C1 as well transcription complex assembly
  • because of its tissue-specific expression, could contribute to tissue-specific genomic occupancy and gene regulation by Steroid receptors (SRs)
  • important role in regulation of aqueous humor (AH) outflow through the trabecular meshwork (TM) in both normal and glaucomatous eyes
  • is required for the mechanically dependent generation of stress fibers in response to TGFB1
  • TGFB1I1 and HIPK1 assist MYB in recruiting the coactivator and acetyltransferase EP300 to chromatin
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can bind to AR in a ligand-dependent manner
  • can bind to the transforming growth factor-beta (TGF-beta)-signaling regulator SMAD3, thereby inhibiting certain SMAD3-dependent TGF-beta responses
  • can also control TGF-beta responses through an alternative mechanism involving SMAD7, a key negative regulator of TGF-beta signaling
  • binds to SMAD1, SMAD5 and SMAD9, and represses bone morphogenetic protein (BMP) signaling responses
  • physical and mutual functional interaction between TGFB1I1 and the BMP signaling pathway
  • CBLC interacting protein (binding leads to an increase in the ubiquitin ligase activity of CBLC once CBLC has been activated by SRC phosphorylation or through an activating phosphomimetic mutation)
  • TGFB1I1 serves as a novel scaffold protein that specifically activates MAP2K4/MAPK8 pathway, thereby leading to the induction and activation of MMP in smooth muscle cells and subsequent abdominal aortic aneurysm (AAA) formation
  • endogenous TGFB1I1 suppresses senescence and profibrotic activities of myofibroblasts by down-regulating NOX4 protein expression
  • TGFB1I1 and HSPB1, HSPB2 are effectors of NOX4 required for TGFB1-stimulated Focal adhesions (FAs) formation, adhesion strength and migration in vascular smooth muscle cell
  • TGFB1I1 is required for myofibroblast differentiation by regulating mechanically dependent MKL1 nuclear accumulation
  • appears to enhance complex formation between MMP14 and PTK2 in activated endothelial cells, which likely coordinates matrix proteolysis and cell motility
  • TGFB1I1 is a novel interaction partner of the nuclear kinase HIPK1 and TGFB1I1, like HIPK1, also interacts with the transcription factor MYB
  • cell & other
    REGULATION
    induced by TGFB1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased expression of is a feature of nonobstructive azoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    TGFB1I1 can be regarded as a potential therapeutic target for liver fibrosis
    ANIMAL & CELL MODELS
  • Hic-5 deficiency significantly attenuated mouse liver fibrosis and hepatic stellate cell (HSC) activation