Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

TG

contributors: SGE/npt - updated : 19-06-2009

HGNC name	thyroglobulin
HGNC id	11764

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	TG goiter associated to hypothyroidism
Location	8q24.22      Physical location : 133.879.204 - 134.147.141
Synonym symbol(s)	TGN, AITD3
EC.number	2.3.2.13

DNA

TYPE	functioning gene
STRUCTURE	267.94 kb     48 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 48 - 8453 isoform 1 304.6 2768 - Dumont (1989)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage
cell lines	expressed on follicular dendritic cells of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma (Munemasa 2009)
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a carboxy-terminal cholinesterase like (ChEL) domain, critically important in TG export from the endoplasmic reticulum
	11 tyroglobulin type 1 repeats

conjugated

GlycoP

mono polymer

homomer , dimer

isoforms

Precursor

precursor of thyroid hormone

HOMOLOGY

interspecies	homolog to murine Tg (74.3pc)
	homolog to rattus Tg (73.5pc)

Homologene

FAMILY

type B carboxylase/lipase family

CATEGORY

storage , signaling hormone

SUBCELLULAR LOCALIZATION	extracellular
text	secreted protein

basic FUNCTION

involved in storage of iodine and of inactive thyroid hormones

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

hormone

signaling

hormonal , signal transduction

	cell to cell signaling
	hormone biosynthetic process

a component

forming homodimers through the ChEL domains (Lee 2009)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TG

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   mRNA levels are higher in subjects with thyroid disease (Amakawa 2008)

Susceptibility

to autoimmune thyroid disease

Variant & Polymorphism	thyroid hormone synthesis is inhibited because of mutations in the ChEL domain that block protein export from the ER (Lee 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS