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FLASH GENE
Symbol TFPT contributors: mct/npt - updated : 26-10-2016
HGNC name TCF3 (E2A) fusion partner (in childhood Leukemia)
HGNC id 13630
Location 19q13.42      Physical location : 54.610.319 - 54.619.055
Synonym name
  • amida, partner of the E2A and ARC
  • INO80 complex subunit F
  • protein FB1
  • Synonym symbol(s) AMIDA, FB1, INO80F
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text
  • head-to-head arrangement with PRPF31
  • STRUCTURE 8.66 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • responsive to Ikaros2, and PU1 (critical role during the early stages of B cell differentiation )
  • core promoters of PRPF31 and TFPT were conserved between human and monkey
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1223 - 253 low level, several tissues 2011 21303910
    6 - 829 - 244 low levels ubiquitous expressed 2011 21303910
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage hematopoietic cell lines
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two nuclear localization signals (NLS)
  • a domain of interaction with ARC
  • a non-transcriptional immediate early gene specific to the brain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • comodulator with ARC of cell death in brain
  • implicated in cell proliferation and induction of programmed cell death (PCD)(Franchini 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • important binding partner and functional regulator of U19/EAF2, EAF1, and/or ELL)(Jiang 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    promotes caspase 9-dependent apoptosis, nevertheless the apoptotic cascade is engaged only in culture conditions sustaining cell proliferation and different cell lines display differential responsiveness to TFPT induced apoptosis (Franchini 2006)
    constitutional fusion translocation    
    with PBX1 and HLF in pre-B ALL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS