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FLASH GENE
Symbol TFDP3 contributors: mct - updated : 17-03-2020
HGNC name transcription factor Dp family, member 3
HGNC id 24603
Location Xq26.2      Physical location : 132.350.696 - 132.352.376
Synonym name
  • E2F-like protein
  • hepatocellular carcinoma-associated antigen 661
  • cancer/testis antigen 30
  • Synonym symbol(s) CT30, E2F-like, HCA661, MGC161639, DP-4
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 1.69 kb     1 Exon(s)
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1693 - 405 - 2014 24406621
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus     Homo sapiens
     intestinesmall intestine    Homo sapiens
     stomach     Homo sapiens
    Nervousbrain     Homo sapiens
    Reproductivefemale systemovary    Homo sapiens
     female systembreast    Homo sapiens
     female systemuterus    Homo sapiens
     male systemtestis  specific Homo sapiens
    Respiratoryrespiratory tractbronchus    Homo sapiens
    Skin/Tegumentskin     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a heterodimerization domain
  • a DNA binding domain
  • a typical RRXYD E2F DNA recognition motif in the DNA binding domain
  • a C terminus composed of multiple acidic amino acids (15 of the last 20 amino acids are acidic), C-terminal region, outside the DNA-binding domain, required for the negative control of E2F1 activity
  • mono polymer heteromer , dimer
    HOMOLOGY
    intraspecies homolog to TFDP1
    Homologene
    FAMILY
  • E2F/DP family, transcription factor DP(TFDP) family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • translocated to the nucleus of transfected cells in the presence of E2F3 and E2F1
  • basic FUNCTION
  • can stimulate E2F-dependent transcription, and negative regulator of the E2F activity
  • cancer-testis antigen
  • having biological functions that may influence our current perspective of how E2F activities are orchestrated in normal cells and how they are disturbed in such pathological conditions as cancer
  • role for TFDP3 in regulating E2F1 activity during the DNA damage response
  • inactivates transcription, and has the opposite effect compared with TFDP1 on E2F site transcription
  • influences cell cycle progression, under both normal and DNA damage conditions
  • acts as a transcription factor during epithelial-mesenchymal transition
  • functions as a regulator in epithelial-mesenchymal transition
  • contributes toward tumor cell resistance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • able to heterodimerize with individual E2Fs
  • is DNA damage responsive, and in addition, DNA damage favours formation of the E2F-1/DP4 heterodimer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interferes with E2F-1-dependent transcription and delays cell-cycle progression
  • suppress E2F1-induced apoptosis dependent TP53 and play a potential role in carcinogenesis
  • is likely involved in prostate cancer cell survival by suppressing apoptosis induced by E2F1
  • TFDP3 expression can induce autophagy by up-regulating the expression of autophagic key protein LC3(MAP1LC3) and increasing the number of autophagosomes during chemotherapy of malignant tumors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    TFDP3 can be a potential target for tumor therapy
    ANIMAL & CELL MODELS