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FLASH GENE
Symbol TFDP3 contributors: npt - updated : 05-06-2007
HGNC name transcription factor Dp family, member 3
HGNC id 24603
Location Xq26.2      Physical location : 132.350.696 - 132.352.376
Synonym name
  • E2F-like protein
  • hepatocellular carcinoma-associated antigen 661
  • cancer/testis antigen 30
  • Synonym symbol(s) CT30, E2F-like, HCA661, MGC161639, DP-4
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1680 - 345 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a heterodimerization domain
  • a DNA binding domain
  • a typical RRXYD E2F DNA recognition motif in the DNA binding domain
  • a C terminus composed of multiple acidic amino acids (15 of the last 20 amino acids are acidic)
  • HOMOLOGY
    intraspecies homolog to TFDP1
    Homologene
    FAMILY
  • E2F/DP family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • translocated to the nucleus of transfected cells in the presence of E2F3 and E2F1
  • basic FUNCTION
  • can stimulate E2F-dependent transcription, and negative regulator of the E2F activity
  • cancer-testis antigen
  • having biological functions that may influence our current perspective of how E2F activities are orchestrated in normal cells and how they are disturbed in such pathological conditions as cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • able to heterodimerize with individual E2Fs
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interferes with E2F-1-dependent transcription and delays cell-cycle progression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS