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FLASH GENE
Symbol TFDP2 contributors: mct - updated : 14-05-2018
HGNC name transcription factor Dp-2 (E2F dimerization partner 2)
HGNC id 11751
Location 3q23      Physical location : 141.663.276 - 141.868.386
Synonym symbol(s) DP2, Dp-2
DNA
TYPE functioning gene
STRUCTURE 77.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 9908 49.2 446 - 1996 8755520
14 - 9946 43 386 - 1996 8755520
10 - 9337 39.2 349 - 1996 8755520
11 - 9462 43 386 - 1996 8755520
10 - 9404 46.3 418 - 1996 8755520
8 - 9185 34.7 310 - 1996 8755520
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
 salivary gland   highly
Lymphoid/Immunelymph node   highly
 thymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a heterodimerization domain
  • a DNA binding domain
  • a typical RRXYD E2F DNA recognition motif in the DNA binding domain
  • a C terminus composed of multiple acidic amino acids (15 of the last 20 amino acids are acidic
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY E2F/DP family, transcription factor dimerization partner (DP) family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • DP2/E2F complex functioning in the control of cell-cycle progression from G1 to S phase
  • the E2F-1/DP complex appears to mediate both cell
  • proliferation and apoptosis
  • is a critical cofactor required for proper cell cycle control and gene expression
  • importance of TFDP2 in coupling the erythroid cell cycle with terminal differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerizing with E2F family members
    INTERACTION
    DNA
    RNA
    small molecule
    protein interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (p107 and p130)
    that inhibit the E2F transactivation domain
  • role of PRPF39 as a potential regulator of TFDP2 represents an interesting area of further study regarding the role of TFDP2 and cisplatin response
  • GATA1 and TAL1 are bound to the regulatory regions of TFDP2 and upregulate its expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS