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FLASH GENE
Symbol TFDP1 contributors: - updated : 29-03-2006
HGNC name transcription factor Dp-1
HGNC id 11749
Location 13q34      Physical location : 114.239.002 - 114.295.786
Synonym symbol(s) DP1, Dp-1, DRTF1
DNA
TYPE functioning gene
STRUCTURE 56.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC390426 13 similar to mKIAA0324 protein SOX1 13q34 SRY (sex determining region Y)-box 1 LOC387948 13 LOC387948 LOC122258 13q34 LOC122258 TUBGCP3 13q34 tubulin, gamma complex associated protein 3 LOC387949 13 LOC387949 ATP11A 13q34 ATPase, Class VI, type 11A LOC387950 13 LOC387950 MCF2L 13q34 MCF.2 cell line derived transforming sequence-like F7 13q34 coagulation factor VII (serum prothrombin conversion accelerator) F10 13q34 coagulation factor X PROZ 13q34 protein Z, vitamin K-dependent plasma glycoprotein FLJ11305 13q34 hypothetical protein FLJ11305 CUL4A 13q34-qter cullin 4A LAMP1 13q34 lysosomal-associated membrane protein 1 GRTP1 4q14 growth hormone regulated TBC protein 1 LOC387951 13 LOC387951 ADPRHL1 13q34 ADP-ribosylhydrolase like 1 C13orf17 13q34 chromosome 13 open reading frame 17 C13orf11 13q34 chromosome 13 open reading frame 11 TFDP1 13q34 transcription factor Dp-1 ATP4B 13q34 ATPase, H+/K+ exchanging, beta polypeptide RHOK 13q34 rhodopsin kinase LOC387952 13 hypothetical gene supported by AK126042; BC034570 GAS6 13q34 growth arrest-specific 6 MGC20579 13q34 hypothetical protein MGC20579 RASA3 13q34 RAS p21 protein activator 3 LOC390427 13 LOC390427 CDC16 13q34 CDC16 cell division cycle 16 homolog (S. cerevisiae) UPF3A 13q34 UPF3 regulator of nonsense transcripts homolog A (yeast) C13orf8 13q34 chromosome 13 open reading frame 8
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 stomach   highly
Nervousbrain    
Reproductivefemale systemuteruscervix highly
Urinarybladder   highly
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a heterodimerization domain
  • a DNA binding domain
  • a typical RRXYD E2F DNA recognition motif in the DNA binding domain
  • a C terminus composed of multiple acidic amino acids (15 of the last 20 amino acids are acidic)
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY E2F/DP family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION playing an important role in regulating the expression of genes that are required for passage through the cell cycle
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerizing with E2F family member
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in esophageal squamous cell carcinoma and hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS