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FLASH GENE
Symbol TFAP4 contributors: mct - updated : 24-04-2017
HGNC name transcription factor AP-4 (activating enhancer binding protein 4)
HGNC id 11745
Location 16p13.3      Physical location : 4.307.187 - 4.323.001
Synonym name
  • class C basic helix-loop-helix protein 41
  • activating enhancer-binding protein 4
  • Synonym symbol(s) AP4, TAP4, AP-4, bHLHc41
    DNA
    TYPE functioning gene
    STRUCTURE 15.81 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Physical map
    ZNF174 16p13.3 zinc finger protein 174 FLJ33071 16p13.3 hypothetical protein FLJ33071 LOC388207 16 LOC388207 FLJ14154 16p13.3 hypothetical protein FLJ14154 LOC390671 16 similar to ribosomal protein L18; 60S ribosomal protein L18 KIAA0643 16p13.3 similar to ribosomal protein L18; 60S ribosomal protein L18 NOD3 16p13.3 NOD3 protein BTBD12 16p13.3 BTB (POZ) domain containing 12 LOC283877 16p13.3 hypothetical LOC283877 DNASE1 16p13.3 deoxyribonuclease I TRAP1 15q25-q26 tumor rejection antigen (gp96) pseudogene 1 CREBBP 16p13.3 CREB binding protein (Rubinstein-Taybi syndrome) ADCY9 16p13.3 adenylate cyclase 9 LOC388208 16 LOC388208 SRL 16p13.3 sarcalumenin TFAP4 16p13 transcription factor AP-4 (activating enhancer binding protein 4) GLIS2 16p13.3 Kruppel-like zinc finger protein GLIS2 Magmas 16p13.3 mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction FLJ22021 16p13.3 hypothetical protein FLJ22021 DNAJA3 16p13.3 DnaJ (Hsp40) homolog, subfamily A, member 3 HSCARG 16p13.3 HSCARG protein HMOX2 16p13.3 heme oxygenase (decycling) 2 C16orf5 16p13.3 heme oxygenase (decycling) 2 LOC342346 16p13.3 similar to hypothetical protein DKFZp434P0316 LOC124402 16p13.3 LOC124402 MGRN1 16p13 mahogunin, ring finger 1 SDOS 16p13.3 hypothetical protein MGC11275 LOC146562 16p13.3 hypothetical protein AF447587 ZNF500 16p13.3 zinc finger protein 500 FLJ25410 16p13.3 hypothetical protein FLJ25410 LOC388209 16 hypothetical gene supported by BC022385; BC035868; BC048326 FLJ22386 16p13.3 leucine zipper domain protein N-PAC 16p13.3 cytokine-like nuclear factor n-pac UBN1 16p13.3 ubinuclein 1 PPL 16p13.3 periplakin KIAA0420 16p13.3 periplakin NAGPA 16p13.3 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase MGC45438 16p13.3 hypothetical protein MGC45438 ALG1 16p13.3 asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2147 - 338 - 2014 24500709
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Reproductivefemale systemuteruscervix  
     female systemovary   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    two leucine repeat elements and a helix-loop helix domain
    HOMOLOGY
    interspecies homolog to murine Tfap4
    Homologene
    FAMILY BHLH family of transcription factors
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • involved in signal-mediated trafficking of integral membrane proteins
  • activating both viral and cellular genes by binding to the symmetrical dna sequence 5'- cagctg-3'
  • is a new regulator of EMT that contributes to metastatic processes in CRC and presumably other carcinomas
  • is an oncogenic antagonist of cellular senescence, that achieves this effect by direct repression of CDKN1A, CDKN2A, and may thereby critically contribute to MYC function and tumor progression
  • maintains MYC-initiated cellular activation programs in CD8+ T cells to control microbial infection
  • is a central mediator and coordinator of cell cycle progression in response to mitogenic signals and MYC activation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with GMNN (repressor complex distinct from REST/NRSF to negatively regulate the expression of target genes in nonneuronal cells and may contribute to suppressing the precocious expression of target genes in fetal brain)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transcriptional repressor of PHYHIP
  • interacting with MYC
  • CREB1, SP1, and TFAP4 play roles in modulating PPP2R2B expression
  • modulates reversible and epigenetic silencing of the CD4 gene
  • during the G2 phase of the cell division cycle, TFAP4 is targeted for proteasome-dependent degradation by the BTRC ubiquitin ligase
  • BTRC-dependent degradation of TFAP4 is required for the fidelity of mitotic division
  • TFAP4 is the transcription factor that was induced by MYC and sustained activation of antigen-specific CD8+ T cells
  • direct transcriptional target of MYC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary neuroblastoma patients is associated with poor clinical outcome
    tumoral     --over  
    in primary colorectal cancer (CRC) significantly correlated with liver metastasis and poor patient survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    inhibition of TFAP4 function may represent a therapeutic approach to block tumor cell proliferation
    ANIMAL & CELL MODELS