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FLASH GENE
Symbol TFAP2E contributors: mct - updated : 18-11-2013
HGNC name transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
HGNC id 30774
Location 1p34.3      Physical location : 36.038.970 - 36.060.925
Synonym name
  • adaptor-related protein complex 2, epsilon subunit
  • transcription factor AP-2-epsilon
    • Synonym symbol(s) AP2E, MGC49007
    DNA
    TYPE functioning gene
    STRUCTURE 21.96 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2189 - 442 - 2003 14636996
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • expressed during late chondrocyte differentiation, especially in hypertrophic chondrocyte
    • basic FUNCTION
  • required for olfactory bulb development, specifically the establishment of appropriate neuronal lamination
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • promoter of the type II collagen (COL2A1) gene, is specifically regulated by TFAP2E
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • AP-2epsilon null mice were viable and could discriminate a variety of odors