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FLASH GENE
Symbol TEX19 contributors: mct - updated : 30-08-2010
HGNC name testis expressed 19
HGNC id
Location 17q25.3      Physical location : 80.317.122 - 80.321.649
Synonym name testis-expressed sequence 19 protein
Synonym symbol(s) FLJ35767
DNA
TYPE functioning gene
STRUCTURE 4.53 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1951 18.5 164 - Kuntz (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell
Reproductivespermatogonia
cell lineage pluripotent cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two highly conserved domains that do not present any similarity with any other known domains (Kuntz 2008)
  • HOMOLOGY
    interspecies homolog to murine Tex19.1
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • role in a specialised mechanism that operates in the germline to repress transposable genetic elements and maintain genomic stability through successive generations (Ollinger 2008)
  • could be a new factor involved in the maintenance of self-renewal or pluripotency of stem cells (Kuntz 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds DAZL (may regulate TEX19 expression in germ cells)(Zeng 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker new potential pluripotency marker (Kuntz 2008)
    Therapy target
    ANIMAL & CELL MODELS