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FLASH GENE
Symbol TEX14 contributors: mct/npt - updated : 24-12-2013
HGNC name testis expressed 14
HGNC id 11737
Location 17q22      Physical location : 56.634.038 - 56.769.416
Synonym name
  • testis expressed sequence 14
  • protein kinase-like protein SgK307
  • sugen kinase 307
  • cancer/testis antigen 113
  • Synonym symbol(s) SGK307, CT113
    DNA
    TYPE functioning gene
    STRUCTURE 135.38 kb     33 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MRPS23 17q22-q23 mitochondrial ribosomal protein S23 C14orf34 14q23.2 chromosome 14 open reading frame 34 ZNF161 17q23.3 zinc finger protein 161 SFRS1 17q21.3-q22 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) Dlc2 17q23.2 dynein light chain 2 OR4D1 17q24.2 olfactory receptor, family 4, subfamily D, member 1 HSHPX5 17q23.2 HPX-5 LOC124538 17q23.2 similar to Olfactory receptor 4D2 EPX 17q24-q25 eosinophil peroxidase FLJ20345 17q23.2 hypothetical protein FLJ20345 LPO 17q23.1 lactoperoxidase MPO 17q22-q23.1 myeloperoxidase BZRAP1 17q22-q23 benzodiazapine receptor (peripheral) associated protein 1 SUPT4H1 17q21-q23 suppressor of Ty 4 homolog 1 (S. cerevisiae) FLJ20315 17q23.2 hypothetical protein FLJ20315 FLJ40311 17q23.2 hypothetical protein FLJ40311 MTMR4 1721.1-q23 myotubularin related protein 4 PNUTL2 17q22-q23 peanut-like 2 (Drosophila) FLJ40121 17q23.2 hypothetical protein FLJ40121 TEX14 17q22-q23 testis expressed sequence 14 RAD51C 17q22-q23 RAD51 homolog C (S. cerevisiae) PPM1E 17q23.2 protein phosphatase 1E (PP2C domain containing) TRIM37 17q22-q23 tripartite motif-containing 37 LOC348235 17q23.2 hypothetical protein LOC348235 FLJ11029 17q23.2 hypothetical protein FLJ11029 FLJ10587 17q23.2 hypothetical protein FLJ10587 FLJ37451 17q23.2 hypothetical protein FLJ37451 LOC388403 17 similar to Yippee-like protein 2 (DiGeorge syndrome-related protein FKSG4)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 4825 - 1451 - 2003 12711554
    33 - 4945 - 1491 - 2003 12711554
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivemale systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    Reproductivespermatocyte
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three ankyrin repeats
  • a protein kinase domain
  • and a leucine zipper dimerization motif (Wu 2003)
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • predicted to be localized to the nucleus (Wu 2003)
  • localizes to germ cell intercellular bridges (Greenbaum 2006)
  • basic FUNCTION
  • required for intercellular bridges in vertebrate germ cells and these bridges are essential for spermatogenesis and fertility (Greenbaum 2006)
  • may play a key role in regulating gene expression or modulating nuclear events during mammalian spermatogenesis (Wu 2003)
  • essential component of male and female embryonic intercellular bridges (Greenbaum 2009)
  • TEX14 and intercellular bridges have an essential role in postnatal spermatogenesis, they are not required in the embryo (Greenbaum 2009)
  • is an important mediator of kinetochore structure and function and the fidelity of chromosome separation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CEP55 to block cell abscission (Iwamori 2010)
  • recruited to kinetochores (KTs) by PLK1 in a CDK1-dependent manner during early mitosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    spermatogenesis in Tex14(-/-) mice progresses through the transit amplification of diploid spermatogonia and the expression of early meiotic markers but halts before the completion of the first meiotic division (Greenbaum 2006)