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FLASH GENE
Symbol TEX14 contributors: mct/npt - updated : 24-12-2013
HGNC name testis expressed 14
HGNC id 11737
Location 17q22      Physical location : 56.634.038 - 56.769.416
Synonym name
  • testis expressed sequence 14
  • protein kinase-like protein SgK307
  • sugen kinase 307
  • cancer/testis antigen 113
  • Synonym symbol(s) SGK307, CT113
    DNA
    TYPE functioning gene
    STRUCTURE 135.38 kb     33 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 4825 - 1451 - 2003 12711554
    33 - 4945 - 1491 - 2003 12711554
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivemale systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    Reproductivespermatocyte
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three ankyrin repeats
  • a protein kinase domain
  • and a leucine zipper dimerization motif (Wu 2003)
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • predicted to be localized to the nucleus (Wu 2003)
  • localizes to germ cell intercellular bridges (Greenbaum 2006)
  • basic FUNCTION
  • required for intercellular bridges in vertebrate germ cells and these bridges are essential for spermatogenesis and fertility (Greenbaum 2006)
  • may play a key role in regulating gene expression or modulating nuclear events during mammalian spermatogenesis (Wu 2003)
  • essential component of male and female embryonic intercellular bridges (Greenbaum 2009)
  • TEX14 and intercellular bridges have an essential role in postnatal spermatogenesis, they are not required in the embryo (Greenbaum 2009)
  • is an important mediator of kinetochore structure and function and the fidelity of chromosome separation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CEP55 to block cell abscission (Iwamori 2010)
  • recruited to kinetochores (KTs) by PLK1 in a CDK1-dependent manner during early mitosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    spermatogenesis in Tex14(-/-) mice progresses through the transit amplification of diploid spermatogonia and the expression of early meiotic markers but halts before the completion of the first meiotic division (Greenbaum 2006)