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FLASH GENE
Symbol TEX12 contributors: mct/npt - updated : 09-10-2020
HGNC name testis expressed sequence 12
HGNC id 11734
Location 11q23.1      Physical location : 112.038.094 - 112.043.278
Synonym symbol(s) TX12
DNA
TYPE functioning gene
STRUCTURE 5.18 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1144 14.1 123 - 2018 29932616
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatogonia
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled coil domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • may be meiosis-specific protein
  • TEX12 and TEX15 are essential for correct assembly of the synaptonemal complex and thus meiosis progression
  • regular expression of TEX11, TEX12, TEX14 and TEX15 is essential for the early stages of spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the central element structure of the synaptonemal complex at synapsed homologous chromosomes
  • with SYCE2 form a complex that interacts with SYCE1 (Hamer 2006)
  • SYCE2-TEX12 complex is an equimolar hetero-octamer, formed from the association of an SYCE2 tetramer and two TEX12 dimers
  • synaptic elongation complex SYCE2–TEX12 is essential for extension of the synaptonemal complex (SC) tripartite structure
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PLK1, phosphorylates central element proteins SYCP1 and TEX12, and PLK-mediated phosphorylation of central element proteins is required for meiotic prophase exit
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS