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FLASH GENE

Symbol

TEX11

contributors: mct - updated : 30-09-2020

HGNC name	testis expressed sequence 11
HGNC id	11733

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SPGFX2 spermatogenic failure, X-linked, 2
Location	Xq13.1      Physical location : 69.748.790 - 70.128.567
Synonym symbol(s)	TGC1, TSGA3, MZIP4, SPGFX2, Spo22, ZIP4

DNA

TYPE	functioning gene
STRUCTURE	397.48 kb     30 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001003811 31 - 3134 NP_001003811 - 940 - 2018 29932616 NM_031276 30 - 3012 NP_112566 - 925 - 2018 29932616

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system testis     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatocyte Homo sapiens Reproductive spermatogonia Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	TEX11, testis expressed gene 15 (TEX15), mutL homolog 1 (MLH1), and homolog 3 (MLH3), play critical roles in genome integrity, meiotic recombination, and gametogenesis
	TEX11, involved in the initiation and maintenance of chromosome synapses in meiotic chromosomes, has been shown to be essential for meiosis and fertility in males
	regular expression of TEX11, TEX12, TEX14 and TEX15 is essential for the early stages of spermatogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SHOC1 interacts with TEX11, another protein important for the formation of COs, connecting SHOC1 to chromosome axis and structure
	SHOC1 forms discrete foci on chromosomes axes, and is required for the localization of TEX11 and another ZMM protein, MSH4, to form crossover-prone recombination intermediates

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGFX2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the germ cells may partially contribute to the spermatogenic defect observed in Klinefelter syndrome (KS) patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS