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Symbol TET1 contributors: mct/ - updated : 09-03-2021
HGNC name tet oncogene 1
HGNC id 29484
Location 10q21.3      Physical location : 70.320.116 - 70.454.238
Synonym name
  • leukemia-associated protein with a CXXC domain
  • CXXC finger 6
  • ten-eleven translocation-1
  • methylcytosine dioxygenase TET1
  • Synonym symbol(s) LCX, KIAA1676, bA119F7.1, CXXC6, FLJ10839, FLJ41442, FLJ10839
    EC.number 1.14.11.n2
    TYPE functioning gene
    STRUCTURE 134.12 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 9601 235.2 2136 - -
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Reproductivefemale systemovary   
    Respiratoryrespiratory tractlarynx   
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
    physiological period embryo, fetal
    Text embryonic stem cells, fetal lung, brain, heart, thymus, ovary
  • a zinc-binding CXXC domain (which MLL also contains) within a methyltransferase domain, a domain known to bind to unmethylated CpG sites, which are present abundantly in CpG islands
  • three nuclear localizations signals
  • an alpha-helical coiled-coil region
    interspecies ortholog to murine Cxxc6
  • TET family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • having zinc ion binding, DNA binding activities
  • could catalyse the conversion of 5-methylcytosine (5mC) of DNA to 5-hydroxymethylcytosine (5hmC), raising the possibility that DNA demethylation may be a TET1-mediated process
  • role for TET1 in regulating DNA methylation status
  • seems to have a role in maintaining ES cell fate, which is consistent with its role in ICM (inner cell mass) cell specification
  • potential TET1-induced oxidation-deamination mechanism for active DNA demethylation in mammals
  • critical factor to initiate an oxidation-deamination mechanism underlying active DNA demethylation in mammals
  • required for neuronal activity-induced, region-specific, active DNA demethylation and gene expression in the adult brain
  • dual biological role of TET1, one in which it removes aberrant DNA methylation and another that ensures the timely DNA methylation and silencing of target genes during differentiation
  • has a role in transcriptional repression
  • having an important function in the regulation of DNA methylation fidelity
  • function for TET1 in meiosis and meiotic gene activation in female germ cells
  • specific function of TET1 in germ cell development
  • is required for binding of OGT to chromatin affecting TET1 activity
  • TET1, TET2, TET3 influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling
  • TET1 promotes RASSF5 expression by demethylating a CpG site within RASSF5 promoter
  • TET1 and TET2 play a critical role in maintaining bone marrow MSCs and bone homeostasis through demethylation of P2RX7 to control exosome and miRNA release
  • TET1 is a repressor of both osteogenesis and adipogenesis, and was found to recruit the co-repressor proteins, SIN3A and the histone lysine methyltransferase, EZH2 to osteogenic genes
  • TET1 maintains spermatogonia stem cells with age, revealing an important role of TET1 in regulating stem cell aging
  • suppressive role of TET1 in the thermogenic gene regulation of beige adipocytes is largely DNA demethylase-independent
  • is a potent beige-selective epigenetic breaker of the thermogenic gene program
    a component
  • CXXC5 forms a complex with NANOG, POU5F1, TET1, and TET2 and facilitates their proper recruitment to regulatory regions of pluripotency and TET genes in ESCs to positively regulate their transcription
  • TET1-RNF217-SLC40A1 axis regulates likely iron homeostasis
    DNA DNA binding
    small molecule metal binding,
  • Zn2+
  • protein
  • NANOG is a direct TET1 target and TET1 regulates NANOG expression by preventing the Nanog promoter from hypermethylation
  • interacts with the SIN3A complex and the extensive colocalization of TET1 and the SIN3A co-repressor complex at target genes suggests that SIN3A has an important function in TET1-mediated gene repression
  • function for TET1 in meiosis and meiotic gene activation in female germ cells (
  • link between TETT activities in regulating CpG island methylation
  • PRDM14 maintains pluripotency of embryonic stem cells through TET1, TET2-mediated active DNA demethylation
  • ZFP281 interacts with TET1, but not TET2
  • RASSF5, is the key downstream target of TET1
  • GADD45A binds directly to R-loops and mediates local DNA demethylation by recruiting TET1
  • GADD45A binding to R-loops promotes TET1 recruitment and DNA demethylation at CpG island promoters
  • CXXC5 binds to the chromatin and is enriched at promoters and enhancers of TET1, TET2, and pluripotency genes
  • TET1 interacts with the pluripotency transcription factor NANOG which may contribute to its biological activity in pluripotent cells
  • TET1 binds to CpG dinucleotides in promoters using its CXXC domain, TET1 also binds to enhancers, though the mechanism involved is unknown
  • RNF217 gene is a target of TET1, mediating the ubiquitination and subsequent degradation of SLC40A1
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    to MLL in acute myeloid leukemia with trilineage dysplasia in t(10;11)(q22;q23)
    constitutional       loss of function
    would promote the stochastic hypermethylation of promoters leading to deregulation of transcription and differentiation
    constitutional     --low  
    depletion of TET1 leads to down-regulation of meiotic genes, which causes defective meiotic prophase including accumulation of non-repaired DSBs, and formation of univalent chromosomes
    Susceptibility to late-onset Alzheimer's disease
    Variant & Polymorphism SNP increasing the risk of late-onset Alzheimer's disease
    Candidate gene
    Therapy target
    TET1 enzyme could be a promising therapeutic target to inhibit the persistent inflammation caused by macrophages in chronic inflammatory diseases