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FLASH GENE
Symbol TESK2 contributors: npt - updated : 16-11-2009
HGNC name testis-specific kinase 2
HGNC id 11732
Location 1p34.1      Physical location : 45.809.554 - 45.956.840
EC.number 2.7.12.1
DNA
TYPE functioning gene
STRUCTURE 147.30 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ10597 1p34.1 hypothetical protein FLJ10597 FLJ22353 1p34.1 hypothetical protein FLJ22353 LOC339541 1p34.1 hypothetical LOC339541 LOC256686 1p34.1 hypothetical LOC256686 KIF2C 1p32.2 kinesin family member 2C RPS8 1p32.2-p32.1 ribosomal protein S8 LOC391035 1 similar to 40S ribosomal protein S15a VMD2L2 1p33-p32.3 Homo sapiens vitelliform macular dystrophy 2-like protein 2 (VMD2L2), mRNA. CNK 1p34.1 cytokine-inducible kinase LOC343521 1p34.1 similar to hypothetical protein 4833401D15 LOC388626 1 LOC388626 PTCH2 1p32.3-p32.1 patched homolog 2 (Drosophila) EIF2B3 1p34.1 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa LOC128192 1p34.1 similar to peptidyl-Pro cis trans isomerase FLJ21156 1p34.1 hypothetical protein FLJ21156 UROD 1p34 uroporphyrinogen decarboxylase ZSWIM5 1p34.1 zinc finger, SWIM domain containing 5 MGC15668 1p34.1 hypothetical protein MGC15668 MUTYH 1p34.3-p32.1 mutY homolog (E. coli) TOE1  target of EGR1, member 1 (nuclear) TESK2 1p32 testis-specific kinase 2 LOC126661 1p34.1 hypothetical protein LOC126661 DKFZP564I122 1p34.1 DKFZP564I122 protein PRDX1 1p34.1 peroxiredoxin 1 AKR1A1 1p33-p32 aldo-keto reductase family 1, member A1 (aldehyde reductase) NASP 1p34.1 nuclear autoantigenic sperm protein (histone-binding) FLJ33084 1p34.1 hypothetical protein FLJ33084 SP192 1p34.1 hypothetical protein SP192 LOC51249 1p34.1 hypothetical protein LOC51249 IPP 1p34-p32 intracisternal A particle-promoted polypeptide MAST205 1p33 intracisternal A particle-promoted polypeptide PIK3R3 1p34.1 phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) LOC388627 1 LOC388627 TSPAN-1 1p34.1 tetraspan 1 FLJ20277 RAD54L 1p32 RAD54-like (S. cerevisiae)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3093 - 571 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
ReproductiveSertoli cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tyrosine kinase catalytic domain similar to TESK1 and to those of LIMK1 and LIMK2 kinase
  • HOMOLOGY
    intraspecies homolog to TESK1
    Homologene
    FAMILY
  • protein kinase superfamily
  • TKL Ser/Thr protein kinase family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • kinase activity
  • plays an important role in spermatogenesis (Rosok 1999)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS