Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TESK1 contributors: mct - updated : 20-11-2018
HGNC name testis-specific kinase 1
HGNC id 11731
Location 9p13.3      Physical location : 35.605.280 - 35.610.037
Synonym name
  • testis-specific protein kinase 1
  • testicular protein kinase 1
  • EC.number 2.7.12.1
    DNA
    TYPE functioning gene
    STRUCTURE 4.76 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2559 - 626 - 2008 18216281
    9 - 2443 - 466 - 2008 18216281
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis   
    Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    Reproductivegerm cell
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal protein kinase domain
  • extracatalytic C terminal part highly rich in proline residues
  • LIM motif-containing protein kinase
  • tyrosine kinase catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Tesk1
    Homologene
    FAMILY
  • protein kinase superfamily
  • TKL Ser/Thr protein kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphorylating cofilin and inducing actin cytoskeletal reorganization
  • putatively involved in signal transduction
  • playing a critical role in integrin-mediated actin cytoskeletal reorganization and cell spreading
  • playing an important role at and after the meiotic phase of spermatogenesis
  • the three-way interaction between SPRED1, TAOK1, and TESK1 represents a pathway that links regulation of both the microtubule- and F-actin cytoskeleton (Johne 2008)
  • plays important roles in promyelinating Schwann cells (SCs), potentially through subcellular localization change and participation in integrin-mediated actin reorganization
  • TESK1 regulates podocyte cytoskeletal dynamics in glomerular podocytes and may play an important role in regulating glomerular filtration barrier integrity in glomerular disease processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • YWHAB (to regulating the kinase activity of TESK1 and subcellular localization)
  • interacts with Sprouty-4 (SPRY4)
  • interacts with PARVA to regulate cell spreading on fibronectin
  • interacting with TAOK1 (two new interaction partners of TAOK1, SPRED1 and the testis-specific protein kinase (TESK1)(Johne 2008)
  • TESK1 interacts with SPRY2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling
  • plays an important role in regulating actin reorganization of spreading cell on fibronectin via phosphorylating CFL1
  • actin remodelling factors LIMK2 and TESK1 are key players in the ciliogenesis control network in which YAP1/WWTR1 and directional vesicle trafficking are integral components
  • cell & other
    REGULATION
    inhibited by SPRY4, by binding to it through the C-terminal cysteine-rich region
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS