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FLASH GENE
Symbol TESC contributors: mct - updated : 11-05-2011
Location 12q24.22      Physical location : 117.476.729 - 117.537.251
Genatlas name tescalcin
Synonym name likely ortholog of mouse tescalcin
Synonym symbol(s) FLJ20607, NCCT, CHP3
DNA
TYPE functioning gene
STRUCTURE 60.52 kb     8 Exon(s)
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • likely Sp1 and Sp3 transcription factors cooperate positively in the regulation of Tesc promoter (
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 958 - 187 - 2007 17717601
    8 - 1039 - 214 - 2007 17717601
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
     thyroid    
    Reproductivemale systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four EF-hand calcium-binding domains
  • N-myristolated protein (
    • HOMOLOGY
    interspecies homolog to murine Tsc
    Homologene
    FAMILY calcineurin B homologous protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text lamellipodia
    basic FUNCTION
  • playing a role in concert with SLC9A1 in cardiac tissues
  • regulatory subunit of calcineurim, a calcium-dependent, calmodulin stimulated protein phosphatase,confering calcium sensitivity
  • EF-hand calcium-binding protein, evolutionary conserved during development
  • essential for the coupling of ERK cascade activation with the expression of Ets family genes in megakaryocytic differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC9A1 (interact with the ubiquitous SLC9A1 isoform, but seemingly suppressed its activity)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS