basic FUNCTION
| may be playing a role in telomere length regulation |
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negatively regulating telomere length and its linker region may modulate the recruitment of negative regulators of telomere length |
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multifunctional protein that plays important roles in gene transcription and telomere length regulation, acts both as a repressor or activator on different genes |
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playing a a direct role in the protection of telomeric DNA from nonhomologous end-joining |
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inhibits non-homologous end joining at mammalian telomeres and acts as a mediator of genome stability |
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collaborating with GTF2A1, transduces activating intramolecular signals within the TBP coactivator complex that ultimately can lead to pre-initiation complex formation |
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may play a role in transcriptional control |
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important factor to prevent telomere recombination and fragility, and for transcriptional gene regulation in mammals |
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important for multipolar neurons to polarize their migration toward the cortical plate ( |
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regulates the plasma membrane localization of NCad ( |
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an important regulator of retinal pigment epithelial cell junctions, and is required for maintenance of barrier function ( |
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preferential recruitment of shelterin complex to areas of the telomere where ss- and ds-DNA are in close proximity, such as the 3prime-telomeric overhang, telomeric DNA bubbles and the D-loop at the base of T-loops |
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TERF2IP and TERF2 have the ability to bind to nontelomeric junction sites with similar affinities, raising the question what domain is responsible for the DNA binding ability of TERF2IP |
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is essential for PTP4A3-regulated gene expression and phosphorylation of RELA |
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TLN1 and TERF2IP are critical for resorptive function, and their selective inhibition in mature osteoclasts retards pathological bone loss |
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