| basic FUNCTION
| capping factor protecting the chromosome termini from DNA damage checkpoint and from interchromosome fusion |
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involved in ATM-independent DNA-damage response |
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phosphorylated form may play a key role in both telomere-based and genomic-wide DNA damage signaling responses |
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involved in homologous recombination repair of nontelomeric double-strand breaks |
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plays an essential role in homologous recombination by facilitating the formation of early recombination intermediates |
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playing a role in regulating neuronal differentiation |
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protecting against end-to-end fusion of chromosomes |
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playing a role in successful progression through the cell division cycle |
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an array of TERF2 function as a protein hub and regulate telomeres by recruiting different signaling molecules via a linear sequence code  |
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maintains telomere integrity by controlling turn over of Holliday Junction at t-loops and at regressed replication forks |
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protects telomeric Holliday junctions (HJ) DNA at the t-loop/D-loop from cleavage by endonucleases |
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regulates the 5prime exonuclease activity of its binding partner, DCLRE1B that is required for telomere integrity during S phase |
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with DCLRE1B, act together with TOP2A to protect the inner portion of telomeres from replicative damage and TERF2-DCLRE1B and various topoisomerases are in balanced amounts at telomeres |
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potential role for SIAH1 and TERF2 in TP53-regulated senescence |
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TERF1 and TERF2 couple potentially the functional state of telomeres to the long-range organization of chromosomes and gene regulation networks by binding to extratelomeric sequences |
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preferential recruitment of shelterin complex to areas of the telomere where ss- and ds-DNA are in close proximity, such as the 3prime-telomeric overhang, telomeric DNA bubbles and the D-loop at the base of T-loops |
