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FLASH GENE
Symbol TENM2 contributors: mct - updated : 14-09-2018
HGNC name teneurin transmembrane protein 2
HGNC id 29943
Location 5q34      Physical location : -
Synonym name
  • neurestin alpha
  • tenascin-M2
  • odz, odd Oz/ten-m homolog 2 (Drosophila)
  • Synonym symbol(s) TEN-M2, DKFZp686A1568, TNM2, ODZ2, LASSO
    DNA
    TYPE functioning gene
    STRUCTURE 1285.10 kb     29 Exon(s)
    MAPPING cloned N linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 9645 - 2765 - 2011 21724987
    - splicing - - - highly abundant in the brain 2011 21724987
  • bind LPHN1 (interaction of Lasso and LPHN1 is specific, strong, and functional, leading to intracellular signaling
  • LPHN1 and Lasso are present in synaptic junctions and can form transsynaptic contacts
  • 25 - 9090 - 2535 - 2011 21724987
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     mouthtongue  predominantly
    Nervousbrain   specific Homo sapiens
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text expressed by distinct interconnected populations of neurons in the developing central nervous system
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ectodomains containing eight EGF-like repeats, two of which have unpaired cysteine residues that mediate covalent homodimerization of the molecule
  • distal part of the C terminus, containing 6 NHL and 26 YD repeats
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Odz2
    homolog to the Drosophila pair-rule gene ten-m/odz
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • membrane-bound transcription regulator
  • large cell surface glycoprotein with a single TMR found in all animal species
  • play a role in development, neurite outgrowth, axon guidance, neuronal connectivity, and synaptogenesis
  • requirement for Ten-m2 in the establishment of ipsilateral projections, and thus the generation of binocular circuits, critical for mammalian visual function
  • TENM2 deficiency in human adipocyte precursors leads to induction of brown adipocyte marker genes upon adipogenic differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TENM2 deficiency induces UCP1 expression in differentiating human fat cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS