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FLASH GENE
Symbol TENM1 contributors: mct - updated : 24-04-2014
HGNC name teneurin transmembrane protein 1
HGNC id 8117
Corresponding disease
CLBMX2 isolated colobomatous microphthalmia 2
Location Xq25      Physical location : -
Synonym name
  • tenascin M
  • odz(odd Oz/ten-m Drosophila)homolog 3
  • teneurin-1
  • odz, odd Oz/ten-m homolog 1(Drosophila)
  • Synonym symbol(s) TNM, ODZ3, TNM1, TEN-M1, ODZ1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE escaping inactivation
    text expressed from both chromosomes or from the inactive X chromosome alone
    STRUCTURE 583.00 kb     31 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure
  • EMX2 dependent promoter element (
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Nervousbrain   specific Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text
  • expressed by distinct interconnected populations of neurons in the developing central nervous system
  • predominantly expressed in the developing nervous system in area specific patterns
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • SH2 domain
  • ectodomains containing eight EGF-like repeats, two of which have unpaired cysteine residues that mediate covalent homodimerization of the molecule
  • distal part of the C terminus, containing 6 NHL and 26 YD repeats
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Odz1
    Homologene
    FAMILY
    CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type II transmembrane protein
    basic FUNCTION
  • playing a role in intracellular signaling
  • influences cortical area patterning downstream to EMX2 and PAX6
  • large cell surface glycoprotein with a single TMR found in all animal species
  • play a role in development, neurite outgrowth, axon guidance, neuronal connectivity, and synaptogenesis
  • role in the early development of the human eye
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text
  • anti-pathogen response negative control of cell proliferation neurogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • heparin binding
  • interacting with EMX2 (role of EMXx2 in regulating patterned teneurin expression)
  • HINT1 is a human TENM1 intracellular domain (ICD) interaction partner
  • cell & other
    REGULATION
    Other TENM1 is directly regulated by EMX2 and is expressed during embryonic pattern formation and morphogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s) CLBMX2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in papillary thyroid carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS