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FLASH GENE
Symbol TEKT2 contributors: mct - updated : 30-11-2010
HGNC name tektin 2 (testicular)
HGNC id 11725
Location 1p34.3      Physical location : 36.549.675 - 36.553.875
Synonym name
  • testicular tektin B1-like protein
  • tektin-B1
  • tektin 2
  • Synonym symbol(s) h-tektin-t, TEKTB1, TEK2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 4.21 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1536 49.7 430 - 2002 12029069
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx    
    Hearing/Equilibriumearinner    Homo sapiensAdult
    Reproductivemale systemtestis   
    Respiratoryrespiratory tracttrachea   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumhair cell receptor Homo sapiensAdult
    Reproductivesperm cell
    cell lineage
    cell lines
    fluid/secretion sperm, specific expression in flagella of mature sperm
    at STAGE
    Text lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved tektin motifs
  • five N-glycosylation sites
  • a chaperonin signature motif
  • several serine/threonine and tyrosine kinase phosphorylation sites
  • HOMOLOGY
    interspecies homolog to murine Tekt (83 p100)
    Homologene
    FAMILY
  • tektin family
  • CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • ciliary and flagellar microtubules
  • associates with the spindle poles throughout mitosis, organizes the spindle midzone microtubules during anaphase, and assembles into the midbody matrix surrounding the compacted midzone microtubules during cytokinesis
  • in spermatozoa, might be present in the peri-axonemal component, not directly associated with axonemal tubulins
  • basic FUNCTION
  • playing a role in the formation of the sperm flagella and/or sperm mobility
  • filament-forming protein coassembled with tubulins to form ciliary and flagellar microtubules
  • may playing a role in spermatogenesis
  • required for central spindle microtubule organization and the completion of cytokinesis
  • TEKT2-dependent organization of the central spindle during anaphase is essential for proper midbody formation and the segregation of daughter cells after cytokinesis
  • involved in the stability and structural complexity of axonemal microtubules
  • may function as an outer dense fibers-affiliated molecule required for flagellum stability and sperm motility
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • coassembling with tubulins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS