protein
| receptor of ANGPT1 |
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HOXA13 directly regulates TEK and FOXF1 in the placental labyrinth endothelia  |
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interacting with ABCG2, ABCC2 (downmodulation of ABCG2 or ABCC2 resulted in the inability of TEK activation to induce a chemoresistant phenotype) |
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bind to GATA3  |
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TIE1-TEK interactions are dynamic, inhibitory, and differentially modulated by ANGPT1 and ANGPT2  |
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ST14 interacts with TEK and degrades the TEK extracellular portion that contains the ligand-binding domain  |
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molecular balance between receptor tyrosine kinases TIE1 and TEK is dynamically controlled by VEGF and TNF and regulates angiopoietin signalling  |
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expression level of TIE1 and its physical interaction with TEK defines whether ANGPT2 functions as a TEK2 agonist or antagonist, thereby determining the context-dependent differential endothelial sensitivity to ANGPT2  |
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ANGPT1 signaling via the TEK receptor regulates vascular and hematopoietic systems  |
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ligand-independent dimerization of TEK is essential for a strong response upon stimulation with high dose ANGPT1  |
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under hypoxic conditions, TIE1 is critical for reducing ANGPT1-induced TEK activity and angiogenesis  |
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overexpression of CASP5 can promote the angiogenesis significantly, possibly by inhibiting the ANGPT1/TEK pathway and promoting VEGFA pathway  |