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FLASH GENE

Symbol

TEF

contributors: np/ - updated : 19-10-2005

HGNC name	thyrotrophic embryonic factor
HGNC id	11722

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.2      Physical location : 41.763.391 - 41.795.328
Synonym name	thyrotroph embryonic factor
Synonym symbol(s)	KIAA1655

DNA

TYPE	functioning gene
STRUCTURE	31.94 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003216 4 - 4382 NP_003207 - 303 - - NM_001145398 4 - 4349 NP_001138870 - 273 - -

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly   thymus       highly Digestive liver         endocrine brain diencephalon pituitary     Nervous brain       highly Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Endocrine thyrotrophs

cell lineage
cell lines	pituitary cell line
fluid/secretion

at STAGE

physiological period

embryo

Text	developing pituitary gland thyrotroph

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

proline and acidic AA rich,basic leucine zipper

mono polymer

homomer , heteromer , dimer

HOMOLOGY

intraspecies

homolog to albumin D-box

Homologene

FAMILY	PAR (proline and acidic amino-acids rich) family
	bZIP family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	expressed in kidney according to a robust circadian rhythm
	transcription factor binding to and transactivating the TSHB promoter

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

circadian , development

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS