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FLASH GENE
Symbol TECPR1 contributors: mct - updated : 24-10-2018
HGNC name tectonin beta-propeller repeat containing 1
HGNC id 22214
Location 7q21.3      Physical location : 97.846.059 - 97.881.468
DNA
TYPE functioning gene
STRUCTURE 36.81 kb     26 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 5752 - 1165 - 2011 21795850
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • critical role of the C-terminal unstructured region of the AIR domain of TECPR1 in induced autophagy
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • TECPR1-dependent pathway is important in targeting bacterial pathogens for selective autophagy 9)
  • TECPR1 activity is required for efficient autophagy to target bacteria, but a deficiency of TECPR1 in host cells does not have a marked effect on canonical autophagy
  • TECPR1 and ATG16L1 share the same binding site on ATG5 (swapping of interaction partners with ATG5 for autophagosome maturation)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • concerted interactions among TECPR1, ATG12-ATG5, and PtdIns(3)P provide the fusion specificity between autophagosomes and lysosomes and the assembly of this complex initiates the autophagosome maturation process
  • during process of induced autophagy, the ATG12-ATG5 conjugate requires 2 different binding partners, ATG16L1 for autophagosome elongation and TECPR1 for lysosomal fusion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS