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FLASH GENE
Symbol TEC contributors: mct/npt - updated : 12-10-2009
HGNC name tec protein tyrosine kinase
HGNC id 11719
Location 4p12      Physical location : 48.137.800 - 48.271.814
Synonym symbol(s) MGC126760, MGC126762, PSCTK4
EC.number 2.7.1.112, 2.7.10.2
DNA
TYPE functioning gene
STRUCTURE 134.01 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif
MAPPING cloned Y linked N status confirmed
Physical map
KCTD8 4p13 potassium channel tetramerisation domain containing 8 FLJ39576 4p13 hypothetical protein FLJ39576 FLJ13220 4p13 hypothetical protein FLJ13220 GNPDA2 4p13 glucosamine-6-phosphate deaminase 2 LOC391648 4 similar to ribosomal protein L4; 60S ribosomal protein L4; homologue of Xenopus ribosomal protein L1 GABRG1 4p14-q21.1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 GABRA2 4p13-p12 gamma-aminobutyric acid (GABA) A receptor, alpha 2 LOC256000 4p13 similar to ras-related C3 botulinum toxin substrate 1 isoform Rac1; rho family, small GTP binding protein Rac1 COX7B2 4p13 cytochrome c oxidase subunit VIIb2 GABRA4 4p14-p12 gamma-aminobutyric acid (GABA) A receptor, alpha 4 GABRB1 4p13-p12 gamma-aminobutyric acid (GABA) A receptor, beta 1 FLJ20502 4p12 hypothetical protein FLJ20502 ATP10D 4p13-q13.1 ATPase, Class V, type 10D CRN 4p13-p12 corin HOZFP 4p12 ovarian zinc finger protein CNGA1 4p14-q13 cyclic nucleotide gated channel alpha 1 LOC152519 4p12 hypothetical protein LOC152519 TXK 4p12 TXK tyrosine kinase TEC 4p12 tec protein tyrosine kinase KIAA1458 4p12 KIAA1458 protein SLC10A4 4p12 solute carrier family 10 (sodium/bile acid cotransporter family), member 4 ZAR1 4p11 zygote arrest 1 KIAA0826 4p12 KIAA0826 protein OCIA 4q11 KIAA0826 protein MGC45416 4p12 hypothetical protein MGC45416 FLJ21511 4p12 hypothetical protein FLJ21511 LOC391649 4 similar to SNAG1 LOC391650 4 similar to SNAG1 LOC391651 4 similar to SNAG1 LOC391652 4 similar to SNAG1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3620 73.6 631 - Sato, Zemans (2009)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Homo sapiens
Endocrineadrenal gland   highly
 neuroendocrinepituitary  highly
Respiratoryrespiratory tractlarynx   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil Homo sapiens
Digestivehepatocyte Homo sapiens
cell lineage hemocytopoietic cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH)
  • a SH2, a SH3 domains (SRC family, Tec subfamily)
  • a BTK-type zinc finger
  • a protein kinase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • TEC subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in T cell activation
  • involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules
  • playing an essential role in phospholipase Cgamma (PLCgamma) activation following antigen receptor stimulation
  • regulate activation of the MAPKs in other cell systems, and may be an upstream component of the signaling pathway leading to LPS-induced MAPKs activation in neutrophils (Zemans 2009)
  • principal kinase of the Tec family that plays a major role in the responses of neutrophils to monosodium urate monohydrate crystals, which are likely to be involved in the initiation and perpetuation of gout (Popa-Nita 2008)
  • may regulate hepatocyte differentiation and is involved in HGF signaling
  • promotes the Erk-MAPK signaling pathway and acts downstream of MEK1 kinase but upstream of ERK kinase in HGF signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 zinc ion per subunit
  • protein
  • with CD28 receptor
  • with SHIP1 and SHIP2
  • cell & other
    REGULATION
    activated by CD3 or CD28
    inhibited by SHIP1 and SHIP2 (inhibition of its membrane localization)
    Other activated during liver regeneration
    upregulated during carly phase of liver regeneration
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in myelodysplastic syndrome
    tumoral fusion      
    with TAF15 in extraskeletal myxoid chondrosarcoma (Kim 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS