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FLASH GENE
Symbol TEAD2 contributors: npt/mct - updated : 20-08-2010
HGNC name TEA domain family member 2
HGNC id 11715
Location 19q13.33      Physical location : 49.843.856 - 49.865.714
Synonym name SV40-transcriptional enhancer factor 4 (TEF4)
Synonym symbol(s) TEF4, ETF, TEF-4, TEAD-2
DNA
TYPE functioning gene
STRUCTURE 21.86 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2220 - 447 - Tian (2010)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineparathyroid   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text embryo, throughout the embryo from the onset of gene expression
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal DNA-binding TEA (TEF-1, TEC1, and AbaA) domain
  • a C-terminal YAP-binding domain (YBD)(Tian 2010)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for cardiac muscle and skeletal muscle specific genes expression
  • may be involved in the gene regulation of neural development
  • playing essential roles in mediating biological functions of YAP1
  • mammalian Tead proteins regulate cell proliferation and contact inhibition as a transcriptional mediator of Hippo signaling (Ota 2008)
  • plays a role in neural tube closure that is independent of its putative role in PAX3 regulation (Kaneko 2007)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    component in the Hippo pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated predominantly with a novel TEAD-binding domain at the amino terminus of YAP1, a powerful transcriptional coactivator
  • interact with YAP1 (which lacks a DNA-binding domain but contains an activation domain) to form functional heterodimeric transcription factors that activate proliferative and prosurvival gene expression programs (Tian 2010)
  • cell & other
    REGULATION
    Other regulated by YAP1 in response to mitogenic signals
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS